Key Laboratory of Environmental Health and Chronic Disease Prevention and Control, School of Public Health, Ningxia Medical University, Yinchuan, Ningxia, People's Republic of China.
Department of Radiology, the General Hospital, Ningxia Medical University, Yinchuan, Ningxia, People's Republic of China.
Genet Test Mol Biomarkers. 2020 Dec;24(12):804-811. doi: 10.1089/gtmb.2020.0192. Epub 2020 Dec 7.
Upper gastrointestinal tract cancers are the leading causes of cancer-related deaths in Northwest China and they share many similarities in terms of histological type, risk factors, and genetic variants. We hypothesized that shared common single-nucleotide polymorphisms (SNPs) in the pathway exist between patients with gastric and esophageal cancer (EC) patients. A case-control study to examine genetic variants in the pathway was conducted with subjects from a high-incidence area for upper gastrointestinal cancers of China. Multiple logistic regression analyses were used to estimate the association of genotypes with gastric cancer and EC risks. Median survival was estimated by using the Kaplan-Meier method and compared by using the log-rank test. Compared with the rs1042522 Pro allele, the rs1042522 Arg allele was associated with an increased risk of gastric cancer (1.810×) and an increased risk of EC (2.285×). The rs1042522 Arg allele carriers who also smoked or consumed alcohol had a further increased risk for gastric cancer odds ratios (OR = 2.422, OR = 5.152) and EC (OR = 5.310, OR = 8.359). No association was found between the rs1042522 genotypes and survival ( > 0.05). The rs1042522 arg allele together with tobacco smoking and alcohol drinking, was associated with an increased risk, for gastric cancer and EC, but not the survival among northwestern Chinese patients. These associations warrant confirmatory studies.
上消化道癌症是中国西北地区癌症相关死亡的主要原因，它们在组织学类型、危险因素和遗传变异方面有许多相似之处。我们假设胃癌和食管癌（EC）患者之间存在途径中共同的常见单核苷酸多态性（SNP）。我们在中国高发上消化道癌地区进行了一项病例对照研究，以检查途径中的遗传变异。采用多元逻辑回归分析来估计基因型与胃癌和 EC 风险的关联。采用 Kaplan-Meier 方法估计中位生存时间，并采用对数秩检验进行比较。与 rs1042522 Pro 等位基因相比，rs1042522 Arg 等位基因与胃癌（1.810×）和 EC（2.285×）风险增加相关。携带 rs1042522 Arg 等位基因且同时吸烟或饮酒的患者，胃癌（比值比[OR] = 2.422，OR = 5.152）和 EC（OR = 5.310，OR = 8.359）的风险进一步增加。rs1042522 基因型与生存之间没有关联（>0.05）。rs1042522 Arg 等位基因与吸烟和饮酒一起，与胃癌和 EC 的风险增加相关，但与西北中国患者的生存无关。这些关联需要进一步的证实性研究。
