Faculty of Pharmacy, Department of Pharmacognacy, University of Kufa, AL-Najaf, Iraq.
Pharmacognacy, Pharmacy, University of Kufa, AL-Najaf, Iraq.
Curr Diabetes Rev. 2021;17(6):e120720188794. doi: 10.2174/1573399817666201207200346.
For thousands of years, natural food products have been used as a medicine for treating diseases that affect the human body, including diabetes mellitus (DM). Lately, several investigations have been performed on the flavonoid derivatives of plant origin, and their biological activity has been extensively studied.
Given our need to know more mechanisms for treating DM, we performed a thorough research review on treating diabetes mellitus based on flavonoids, their therapeutic potential, and biological action.
Flavonoids reduce complications in addition to their vital role as effective supplements for preventing diabetes mellitus by regulating glucose metabolism, lipid profile, liver enzyme activity, a protein kinase inhibitor, PPAR, and AMPK with NF-κB.
The articles that we reviewed showed the positive role of flavonoids, which in a certain way reduce diabetes, but their side effects still need to be studied further.This review is focused on describing the different types of dietary flavonoids along with their mechanisms of reducing blood glucose and enhancing insulin sensitivity, as well as their side effects.
几千年来，天然食品一直被用作治疗影响人体的疾病的药物，包括糖尿病（DM）。最近，对植物来源的类黄酮衍生物进行了多项研究，并广泛研究了它们的生物学活性。
鉴于我们需要更多了解治疗糖尿病的机制，我们对基于类黄酮的治疗糖尿病的方法进行了全面的研究综述，包括其治疗潜力和生物学作用。
类黄酮除了作为预防糖尿病的有效补充剂在调节葡萄糖代谢、脂质谱、肝酶活性、蛋白激酶抑制剂、PPAR 和 AMPK 与 NF-κB 方面发挥重要作用外，还能减少并发症。
我们综述的文章表明了类黄酮的积极作用，它在某种程度上降低了糖尿病的发病率，但它们的副作用仍需要进一步研究。本综述重点描述了不同类型的膳食类黄酮及其降低血糖和增强胰岛素敏感性的机制，以及它们的副作用。
