Chen Jian, Mangelinckx Sven, Adams An, Wang Zheng-Tao, Li Wei-Lin, De Kimpe Norbert
Nat Prod Commun. 2015 Jan;10(1):187-200.
Diabetes mellitus, together with its various complications, is becoming a serious threat to human health. Natural products are secondary metabolites widely distributed in plants, having a broad range of biological activities. The development of antidiabetic medication from natural products, especially those originating from plants with a traceable folk-usage history in treating diabetes, is receiving more attention. Many studies highlighted not only the benefits of natural flavonoids with hypoglycemic effects, but also their importance in the management of diabetic complications. This review describes selected natural flavonoids that have been validated for their hypoglycemic properties, together with their mechanisms of action. Also discussed are their activities in the treatment of diabetic complications demonstrated via laboratory diabetic animal models, in vitro and clinical trials using human subjects. Published papers from 2000 to date on flavonoids and diabetes were covered through accessing Web of Science and multiple databases for biomedical sciences. The major potential benefits of natural flavonoids discussed in this review clearly suggest that these substances are lead compounds with sufficient structural diversity of great importance in the antidiabetic drug developing process.
糖尿病及其各种并发症正成为对人类健康的严重威胁。天然产物是广泛分布于植物中的次生代谢产物，具有广泛的生物活性。从天然产物，特别是那些在治疗糖尿病方面有可追溯民间使用历史的植物中开发抗糖尿病药物，正受到越来越多的关注。许多研究不仅强调了具有降血糖作用的天然黄酮类化合物的益处，还强调了它们在糖尿病并发症管理中的重要性。本综述描述了已被证实具有降血糖特性的选定天然黄酮类化合物及其作用机制。还讨论了通过实验室糖尿病动物模型、体外实验和使用人类受试者的临床试验所证明的它们在治疗糖尿病并发症方面的活性。通过访问科学网和多个生物医学科学数据库，涵盖了2000年至今关于黄酮类化合物和糖尿病的已发表论文。本综述中讨论的天然黄酮类化合物的主要潜在益处清楚地表明，这些物质是在抗糖尿病药物开发过程中具有足够结构多样性的先导化合物，具有重要意义。
