Institute of Molecular Health Sciences, Department of Biology, ETH Zurich, Zurich, Switzerland.
Dev Cell. 2020 Dec 7;55(5):515-517. doi: 10.1016/j.devcel.2020.11.001.
DNA cross-linking agents are common chemotherapeutics for cancer treatment, but their effect on normal cells is largely unknown. In this issue of Developmental Cell, Seldin and Macara (2020) show that such compounds induce epithelial hyperplasia and stem cell fate mis-specification in a non-cell-autonomous manner via inflammasome activation in dermal fibroblasts.
DNA 交联剂是癌症治疗中常用的化疗药物，但它们对正常细胞的影响在很大程度上尚不清楚。在本期《发育细胞》中，Seldin 和 Macara（2020）表明，这些化合物通过皮肤成纤维细胞中炎性体的激活，以非细胞自主的方式诱导上皮细胞增生和干细胞命运异常分化。
