窥探肠道奥秘：基于生物灵感的迷你肠道管体外工程。

A Window into Your Gut: Biologically Inspired Engineering of Mini-gut Tubes In Vitro.

机构信息

Center for Stem Cell and Organoid Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA; Division of Pediatric General and Thoracic Surgery, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.

Center for Stem Cell and Organoid Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA; Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229-3039, USA; Division of Endocrinology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229-3039, USA.

出版信息

Dev Cell. 2020 Dec 7;55(5):522-524. doi: 10.1016/j.devcel.2020.11.015.

DOI:10.1016/j.devcel.2020.11.015

PMID:33290692

Abstract

Recently in Nature, using biologically inspired design principles to recapitulate native crypt-villi topography and luminal flow, Nikolaev et al. engineered an intestinal organotypic culture system that is capable of long-term epithelial homeostasis. Mini-gut tubes were used in month-long studies of parasite-host interactions and completely regenerated following injury.

摘要

最近在《自然》杂志上，Nikolaev 等人利用受生物启发的设计原则来重现天然隐窝-绒毛状结构和管腔流，构建了一种能够实现长期上皮稳态的肠道器官型培养系统。在为期一个月的寄生虫-宿主相互作用研究中使用了迷你肠道管，并且在损伤后完全再生。