International Center for Colorectal and Urogenital Care, Children's Hospital Colorado, Aurora, CO, USA; Department of Pediatric Surgery, Children's Hospital Colorado, Aurora, CO, USA.
Developmental Biology and Regenerative Medicine Program, The Saban Research Institute at Children's Hospital Los Angeles, Los Angeles, CA, USA; Department of Surgery, Division of Pediatric Surgery, Children's Hospital Los Angeles, Los Angeles, CA, USA; Keck Medical School, University of Southern California, Los Angeles, CA, USA.
Cell Stem Cell. 2020 Nov 5;27(5):699-701. doi: 10.1016/j.stem.2020.10.010.
Channeling morphogenic signaling gradients intrinsic to intestinal epithelial stem cells, Nikolaev et al. (2020) optimized a three-dimensional microchip perfusion system that augments growth, maturation, and longevity of tubular intestinal enteroids. Reported in Nature, this system may ultimately pave the way to study human intestinal development and pathophysiology, perhaps for therapeutic discovery.
通过引导肠道上皮干细胞内在的形态发生信号梯度，Nikolaev 等人（2020 年）优化了一种三维微芯片灌注系统，该系统可促进管状肠道类器官的生长、成熟和寿命延长。该系统发表在《自然》杂志上，有望最终为研究人类肠道发育和病理生理学铺平道路，也许还能为治疗发现提供新途径。
