Department of Cell and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK.
Department of Cell and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK.
Dev Cell. 2021 Jan 25;56(2):227-239. doi: 10.1016/j.devcel.2020.11.019. Epub 2020 Dec 7.
Durotaxis, the process by which cells follow gradients of extracellular mechanical stiffness, has been proposed as a mechanism driving directed migration. Despite the lack of evidence for its existence in vivo, durotaxis has become an active field of research, focusing on the mechanism by which cells respond to mechanical stimuli from the environment. In this review, we describe the technical and conceptual advances in the study of durotaxis in vitro, discuss to what extent the evidence suggests durotaxis may occur in vivo, and emphasize the urgent need for in vivo demonstration of durotaxis.
趋硬性，即细胞跟随细胞外基质机械硬度梯度的过程，被认为是一种定向迁移的驱动机制。尽管在体内缺乏其存在的证据，但趋硬性已成为一个活跃的研究领域，主要关注细胞对环境力学刺激的反应机制。在这篇综述中，我们描述了体外趋硬性研究的技术和概念进展，讨论了在多大程度上有证据表明趋硬性可能在体内发生，并强调了在体内证明趋硬性的迫切需要。
