Department of Chemistry, Faculty of Sciences, Van Yuzuncu Yil University, 65000 Van, Turkey.
Department of Chemical Engineering, Faculty of Engineering, Van Yuzuncu Yil University, 65000 Van, Turkey.
Int Immunopharmacol. 2021 Jan;90:107232. doi: 10.1016/j.intimp.2020.107232. Epub 2020 Nov 30.
Coronavirus, known as the coronavirus pandemic, is continuing its spread across the world, with over 42 million confirmed cases in 189 countries and more than 1.15 million deaths. Although, scientists focus on the finding novel drugs and vaccine for SARS-CoV-2, there is no certain treatment for it. Antiviral drugs such as; oseltamivir, favipiravir, umifenovir, lopinavir, remdesivir, hydroxychloroquine, chloroquine, azithromycin, ascorbic acid, corticosteroids, are mostly used for patients. They prevent cytokine storm that is the main reason of deaths related to SARS-CoV-2. In addition, anti-inflammatory agents have critical roles to inhibit the lung injury and multisystem organ dysfunction. The combination with anti-viral drugs with other drugs displays high synergistic effects. In the present study, the drugs used for Covid-19 are analyzed and compare the efficiency for the Covid-19 patients from the different continents including USA, South Korea, Italy, Spain, Germany, Russia, Brazil, Turkey, and China. Nowadays, all countries tried to find vaccine and new drug candidates for SARS-CoV-2, but anti-viral drugs may be the best candidates for the treatment of Covid-19 before finding novel anti-Covid drug.
冠状病毒，又称冠状病毒大流行，正在继续在全球范围内传播，在 189 个国家和地区已确认超过 4200 万例病例，超过 115 万人死亡。尽管科学家专注于寻找新型 SARS-CoV-2 药物和疫苗，但目前还没有针对该病毒的特效治疗方法。抗病毒药物，如奥司他韦、法匹拉韦、利巴韦林、洛匹那韦、瑞德西韦、羟氯喹、氯喹、阿奇霉素、维生素 C、皮质类固醇，主要用于治疗患者。这些药物可以预防细胞因子风暴，这是与 SARS-CoV-2 相关死亡的主要原因。此外，抗炎药物在抑制肺损伤和多器官功能障碍方面具有关键作用。抗病毒药物与其他药物联合使用具有很高的协同作用。在本研究中，分析了用于治疗 COVID-19 的药物，并比较了来自美国、韩国、意大利、西班牙、德国、俄罗斯、巴西、土耳其和中国等不同大洲的 COVID-19 患者的疗效。目前，所有国家都在努力寻找针对 SARS-CoV-2 的疫苗和新药候选物，但在找到新型抗 COVID 药物之前，抗病毒药物可能是治疗 COVID-19 的最佳选择。
