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高脂肪饮食喂养的小鼠中 ω-3 脂肪酸和噻唑烷二酮的相加作用：脂肪组织中三酰甘油/脂肪酸循环。

Additive Effects of Omega-3 Fatty Acids and Thiazolidinediones in Mice Fed a High-Fat Diet: Triacylglycerol/Fatty Acid Cycling in Adipose Tissue.

机构信息

Laboratory of Adipose Tissue Biology, Institute of Physiology of the Czech Academy of Sciences, Videnska 1083, 142 20 Prague 4, Czech Republic.

NMR Spectroscopy, Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Flemmingovo Namesti 542/2, 160 00 Prague 6, Czech Republic.

出版信息

Nutrients. 2020 Dec 4;12(12):3737. doi: 10.3390/nu12123737.

DOI:10.3390/nu12123737
PMID:33291653
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7761951/
Abstract

Long-chain n-3 polyunsaturated fatty acids (Omega-3) and anti-diabetic drugs thiazolidinediones (TZDs) exhibit additive effects in counteraction of dietary obesity and associated metabolic dysfunctions in mice. The underlying mechanisms need to be clarified. Here, we aimed to learn whether the futile cycle based on the hydrolysis of triacylglycerol and re-esterification of fatty acids (TAG/FA cycling) in white adipose tissue (WAT) could be involved. We compared Omega-3 (30 mg/g diet) and two different TZDs-pioglitazone (50 mg/g diet) and a second-generation TZD, MSDC-0602K (330 mg/g diet)-regarding their effects in C57BL/6N mice fed an obesogenic high-fat (HF) diet for 8 weeks. The diet was supplemented or not by the tested compound alone or with the two TZDs combined individually with Omega-3. Activity of TAG/FA cycle in WAT was suppressed by the obesogenic HF diet. Additive effects in partial rescue of TAG/FA cycling in WAT were observed with both combined interventions, with a stronger effect of Omega-3 and MSDC-0602K. Our results (i) supported the role of TAG/FA cycling in WAT in the beneficial additive effects of Omega-3 and TZDs on metabolism of diet-induced obese mice, and (ii) showed differential modulation of WAT gene expression and metabolism by the two TZDs, depending also on Omega-3.

摘要

长链 n-3 多不饱和脂肪酸 (Omega-3) 和抗糖尿病药物噻唑烷二酮类 (TZDs) 在对抗饮食肥胖和相关代谢功能障碍方面具有协同作用。需要阐明其潜在机制。在这里，我们旨在了解基于白色脂肪组织 (WAT) 中三酰基甘油水解和脂肪酸再酯化的无效循环 (TAG/FA 循环) 是否可能参与其中。我们比较了 Omega-3（饮食中 30mg/g）和两种不同的 TZDs-吡格列酮（饮食中 50mg/g）和第二代 TZD，MSDC-0602K（饮食中 330mg/g），研究它们对喂食致肥胖高脂肪 (HF) 饮食 8 周的 C57BL/6N 小鼠的影响。饮食单独或与两种 TZD 分别与 Omega-3 联合补充或不补充测试化合物。HF 饮食抑制 WAT 中的 TAG/FA 循环活性。两种联合干预均观察到对 WAT 中 TAG/FA 循环的部分挽救具有相加作用，其中 Omega-3 和 MSDC-0602K 的作用更强。我们的结果 (i) 支持了 WAT 中 TAG/FA 循环在 Omega-3 和 TZDs 对饮食诱导肥胖小鼠代谢的有益协同作用中的作用，以及 (ii) 显示了两种 TZDs 对 WAT 基因表达和代谢的差异调节，这也取决于 Omega-3。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/453d/7761951/35656363782e/nutrients-12-03737-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/453d/7761951/8f7f486a8221/nutrients-12-03737-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/453d/7761951/c42663688d92/nutrients-12-03737-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/453d/7761951/16d8d3a5fe9e/nutrients-12-03737-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/453d/7761951/a15afed465ac/nutrients-12-03737-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/453d/7761951/35656363782e/nutrients-12-03737-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/453d/7761951/8f7f486a8221/nutrients-12-03737-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/453d/7761951/c42663688d92/nutrients-12-03737-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/453d/7761951/16d8d3a5fe9e/nutrients-12-03737-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/453d/7761951/a15afed465ac/nutrients-12-03737-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/453d/7761951/35656363782e/nutrients-12-03737-g010.jpg

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