Ryan B, Connor E, Minnefor A, Desposito F, Oleske J
University of Medicine and Dentistry of New Jersey, Newark.
Hematol Oncol Clin North Am. 1987 Sep;1(3):381-95.
HIV infection in pediatric patients is a multisystem chronic disease that manifests as a clinical spectrum from asymptomatic infection through symptomatic infection with opportunistic infections and malignancies. The hematopoietic system is involved early in the systemic manifestations of this disease. The hematologic abnormalities seen are most probably a reflection of persistent viral infection, inflammation, and immune dysregulation, and may be complicated by secondary infections, chronic disease, drug toxicities, and nutritional deficiencies. Anemia and lymphopenia are commonly found in adult AIDS patients. Although both are also seen in pediatric patients, lymphopenia is much less common. Atypical lymphocytes with plasmacytoid characteristics have been identified in both adults and children. Pediatric bone marrow evaluation has shown an increase in plasma cells and plasmacytoid lymphocytes. Besides these findings, adult marrow findings include an increase in reticulum and lymphocytes appearing in a diffuse or aggregate pattern.
儿科患者的HIV感染是一种多系统慢性疾病，其临床表现范围从无症状感染到伴有机会性感染和恶性肿瘤的有症状感染。造血系统在该疾病的全身表现中早期就会受累。所观察到的血液学异常很可能是持续性病毒感染、炎症和免疫失调的反映，并且可能因继发感染、慢性疾病、药物毒性和营养缺乏而复杂化。贫血和淋巴细胞减少在成年艾滋病患者中很常见。虽然在儿科患者中也会出现这两种情况，但淋巴细胞减少要少见得多。在成人和儿童中均已发现具有浆细胞样特征的非典型淋巴细胞。儿科骨髓评估显示浆细胞和浆细胞样淋巴细胞增多。除了这些发现外，成人骨髓的发现还包括网状细胞增多以及淋巴细胞呈弥漫性或聚集性出现。
