Headache Unit, Neurology Department, Hospital Universitari Vall d'Hebron, Barcelona, Spain.
Headache Research Group, Vall d'Hebron Research Institute (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain.
Cephalalgia. 2021 Apr;41(5):613-630. doi: 10.1177/0333102420974359. Epub 2020 Dec 8.
Validated chronic migraine biomarkers could improve diagnostic, prognostic, and predictive abilities for clinicians and researchers, as well as increase knowledge on migraine pathophysiology.
The objective of this narrative review is to summarise and interpret the published literature regarding the current state of development of chronic migraine biomarkers.
Data from functional and structural imaging, neurophysiological, and biochemical studies have been utilised towards the development of chronic migraine biomarkers. These biomarkers could contribute to chronic migraine classification/diagnosis, prognosticating patient outcomes, predicting response to treatment, and measuring treatment responses early after initiation. Results show promise for using measures of brain structure and function, evoked potentials, and sensory neuropeptide concentrations for the development of chronic migraine biomarkers, yet further optimisation and validation are still required.
Imaging, neurophysiological, and biochemical changes that occur with the progression from episodic to chronic migraine could be utilised for developing chronic migraine biomarkers that might assist with diagnosis, prognosticating individual patient outcomes, and predicting responses to migraine therapies. Ultimately, validated biomarkers could move us closer to being able to practice precision medicine in the field and thus improve patient care.
经过验证的慢性偏头痛生物标志物可以提高临床医生和研究人员的诊断、预后和预测能力，同时增加对偏头痛病理生理学的了解。
本综述的目的是总结和解释有关慢性偏头痛生物标志物当前发展状况的已发表文献。
功能和结构成像、神经生理学和生物化学研究的数据已被用于开发慢性偏头痛生物标志物。这些生物标志物可以帮助慢性偏头痛的分类/诊断、预测患者的预后、预测对治疗的反应，以及在治疗开始后早期测量治疗反应。结果表明，使用大脑结构和功能、诱发电位和感觉神经肽浓度的测量值来开发慢性偏头痛生物标志物具有前景，但仍需要进一步优化和验证。
从阵发性偏头痛到慢性偏头痛进展过程中发生的影像学、神经生理学和生物化学变化可用于开发慢性偏头痛生物标志物，这些标志物可能有助于诊断、预测个体患者的预后，并预测偏头痛治疗的反应。最终，经过验证的生物标志物可以使我们更接近在该领域实施精准医疗，从而改善患者的护理。
