Domitrz Izabela, Golicki Dominik
Department of Neurology, Faculty of Medical Sciences, Medical University of Warsaw, 80 Cegłowska St., 01-809 Warsaw, Poland.
Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, Żwirki i Wigury 61, 02-091 Warsaw, Poland.
J Clin Med. 2022 Nov 24;11(23):6925. doi: 10.3390/jcm11236925.
Migraine leads to moderate to severe disabilities and disrupts family life, interpersonal relationships, and professional life, and is the second leading cause of disability worldwide. Many people with migraine suffer prolonged headaches and frequent migraine attacks, transition to having chronic migraine, and have the highest number of disability-adjusted life-years. The aim of this study is to measure the quality of life in migraineurs based on the EQ-5D-5L questionnaire.
We assessed 100 consecutive patients diagnosed with migraine: 70 with episodic migraine and 30 with chronic migraine. Migraineurs were asked to complete the EQ-5D-5L. The control group (n = 100), matched for sex and age group, was created based on the results of the population norms study for the EQ-5D-5L in the general population of Poland.
Patients with migraine had worse HRQoL than the matched general population control group for all three primary endpoints of the EQ-5D-5L questionnaire: dimensions, EQ-5D-5L Index and EQ VAS.
Migraine is a disease that disrupts daily function, and as a lifelong disease, plays a role in every aspect of it. Proving a negative impact on many aspects helps to make decisions about treatment, especially in the context of the design and reimbursement of drugs.
偏头痛会导致中度至重度残疾，扰乱家庭生活、人际关系和职业生活，是全球第二大致残原因。许多偏头痛患者会经历长时间的头痛和频繁的偏头痛发作，进而转变为慢性偏头痛，并且其伤残调整生命年数最多。本研究的目的是基于EQ-5D-5L问卷来衡量偏头痛患者的生活质量。
我们评估了100例连续诊断为偏头痛的患者：70例发作性偏头痛患者和30例慢性偏头痛患者。要求偏头痛患者完成EQ-5D-5L问卷。对照组（n = 100）根据波兰普通人群中EQ-5D-5L的人群规范研究结果创建，在性别和年龄组上进行匹配。
对于EQ-5D-5L问卷的所有三个主要终点：维度、EQ-5D-5L指数和EQ视觉模拟量表，偏头痛患者的健康相关生活质量均低于匹配的普通人群对照组。
偏头痛是一种扰乱日常功能的疾病，作为一种终身疾病，在生活的各个方面都有影响。证明其对许多方面有负面影响有助于做出治疗决策，尤其是在药物设计和报销方面。
