Department of Spinal Surgery, Peking University People's Hospital, Peking University, Beijing, P.R. China.
Beijing National Laboratory for Molecular Sciences, Key Laboratory of Molecular Nanostructure and Nanotechnology, CAS Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing, P.R. China.
J Neurotrauma. 2021 May 1;38(9):1203-1224. doi: 10.1089/neu.2020.7413. Epub 2021 Feb 16.
The blood-spinal cord barrier (BSCB), a physical barrier between the blood and spinal cord parenchyma, prevents the toxins, blood cells, and pathogens from entering the spinal cord and maintains a tightly controlled chemical balance in the spinal environment, which is necessary for proper neural function. A BSCB disruption, however, plays an important role in primary and secondary injury processes related to spinal cord injury (SCI). After SCI, the structure of the BSCB is broken down, which leads directly to leakage of blood components. At the same time, the permeability of the BSCB is also increased. Repairing the disruption of the BSCB could alleviate the SCI pathology. We review the morphology and pathology of the BSCB and progression of therapeutic methods targeting BSCB in SCI.
血-脊髓屏障（BSCB）是血液和脊髓实质之间的物理屏障，可防止毒素、血细胞和病原体进入脊髓，并维持脊髓环境中严格控制的化学平衡，这对于正常的神经功能是必要的。然而，BSCB 的破坏在与脊髓损伤（SCI）相关的原发性和继发性损伤过程中起着重要作用。SCI 后，BSCB 的结构被破坏，这直接导致血液成分的渗漏。同时，BSCB 的通透性也增加。修复 BSCB 的破坏可以减轻 SCI 的病理学。我们回顾了 BSCB 的形态和病理学以及针对 SCI 中 BSCB 的治疗方法的进展。
