宿主蛋白二硫键异构酶2（PDIA2）中的基因变异与沙眼衣原体感染易感性相关。
Genetic Variants in Host Protein Disulfide Isomerase 2 (PDIA2) are Associated with Susceptibility to Chlamydia Trachomatis Infection.
作者信息
Zysk Christopher, Williams Steven, Chavarria Itzel, Wilson Hailey, Balogun Adedayo, Jacobs Emily, Kaminski Rachel, Foma Baru-Ta, Johnson Jack, Lux Wesley, McCoy Kristyn, Morales Stephen, Sanchez Gina, Grubb Paul, Littlejohn Melanie, Mize Ryan, Moreno Jorge, Pirtle Caryn, Hendrix Ericka C, Bennett Katie M
机构信息
Molecular Pathology, Department of Laboratory Science and Primary Care, Texas Tech University Health Sciences Center, Lubbock, TX.
Forensic Science, College of Arts and Sciences, Texas Tech University, Lubbock, TX Funded by: The South Plains Foundation.
出版信息
J Assoc Genet Technol. 2020;46(4):244-249.
Objective: Host genetics can influence susceptibility to Chlamydia trachomatis infection. This study examined two genetic variants in human protein disulfide isomerase A2 (PDIA2), a member of a family of protein chaperones that participate in the chlamydial life cycle. Methods: A total of 278 male and female subjects, positive or negative for C. trachomatis infection, were genotyped for PDIA2 polymorphisms (rs400037 and rs419949) using real-time PCR and pyrosequencing. Results: There was a significant odds ratio of 8.21 (95% CI: 1.77-38.16) for rs400037 and 9.89 (95% CI: 1.19-82.10) for rs419949, for the AA genotypes. Conclusion: This indicates that individuals with the PDIA2 AA genotypes have significantly increased susceptibility to C. trachomatis infection as compared to the other PDIA2 genotypes (GG, GA). This correlation may be explained by an interactive role of host protein disulfide isomerases in the attachment and entry of C. trachomatis into cells.
目的
宿主基因可影响沙眼衣原体感染的易感性。本研究检测了人类蛋白质二硫键异构酶A2（PDIA2）中的两个基因变异，该蛋白是参与衣原体生命周期的蛋白质伴侣家族的成员。方法：共有278名沙眼衣原体感染呈阳性或阴性的男性和女性受试者，采用实时PCR和焦磷酸测序对PDIA2多态性（rs400037和rs419949）进行基因分型。结果：对于rs400037，AA基因型的优势比为8.21（95%可信区间：1.77 - 38.16）；对于rs419949，AA基因型的优势比为9.89（95%可信区间：1.19 - 82.10）。结论：这表明与其他PDIA2基因型（GG、GA）相比，PDIA2 AA基因型个体对沙眼衣原体感染的易感性显著增加。这种相关性可能是由于宿主蛋白质二硫键异构酶在沙眼衣原体附着和进入细胞过程中的相互作用。
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