Imhof Reese, Tolkachjov Stanislav N
Mayo Clinic Alix School of Medicine, Rochester, MN, USA.
Epiphany Dermatology, Dallas, TX, USA.
Clin Cosmet Investig Dermatol. 2020 Dec 1;13:897-910. doi: 10.2147/CCID.S235980. eCollection 2020.
Frontal fibrosing alopecia (FFA) is a primary lymphocytic cicatricial alopecia that is often considered a clinical variant of lichen planopilaris (LPP) due to their shared histopathologic features. FFA is characterized by the recession of the frontal, temporal, or frontotemporal hairline; the clinical pattern is distinct and usually includes eyebrow hair loss, as well as other associated symptoms. Pruritus, facial papules, eyelash loss, body hair involvement, and trichodynia may also occur in addition to the frontotemporal recession and eyebrow loss classically seen. Early diagnosis and prompt treatment are critical as FFA is a progressive disorder that can result in permanent hair loss. FFA is challenging as patients may not present or be recognized until the disease has progressed. Additionally, there is currently no consensus or standard treatment regimen for FFA. While many different therapies have been reported as beneficial, there are a limited number of published guidelines for the treatment of FFA. This article is a review of the literature on treatment modalities for FFA and the objective is to offer a practical guide for clinicians on the evidence-based management options currently available in the literature.
额部纤维性脱发（FFA）是一种原发性淋巴细胞性瘢痕性脱发，由于其与扁平苔藓样毛发角化病（LPP）具有共同的组织病理学特征，常被视为LPP的临床变异型。FFA的特征为额部、颞部或额颞部发际线后移；其临床模式独特，通常包括眉毛脱落以及其他相关症状。除了典型的额颞部后移和眉毛脱落外，还可能出现瘙痒、面部丘疹、睫毛脱落、体毛受累及拔毛痛。由于FFA是一种进行性疾病，可导致永久性脱发，因此早期诊断和及时治疗至关重要。FFA具有挑战性，因为患者在疾病进展之前可能不会出现症状或未被识别。此外，目前对于FFA尚无共识或标准治疗方案。虽然有许多不同的治疗方法被报道有益，但关于FFA治疗的已发表指南数量有限。本文是对FFA治疗方式文献的综述，目的是为临床医生提供一份基于文献中现有循证管理选项的实用指南。
