Taguti Priscila, Dutra Hudson, Trüeb Ralph Michel
Department of Dermatology, University Hospital of the North Parana, State University of Londrina, State University of Londrina, Parana, Brazil.
Center for Dermatology and Hair Diseases Professor Trüeb, Zurich-Wallisellen, Switzerland.
Int J Trichology. 2018 Jul-Aug;10(4):172-174. doi: 10.4103/ijt.ijt_48_18.
Frontal fibrosing alopecia (FFA) represents a distinctive condition with a marginal scarring alopecia along the frontal and temporal hairline. Since its original description, the condition has been recognized to represent a more generalized than localized process, with extension beyond the frontotemporal hairline to include the parieto-occipital hairline and involve peculiar facial papules as evidence of facial vellus hair involvement and loss of peripheral body hair. Finally, the association of FFA with oral lichen planus, nail involvement, and concomitant lichen planopilaris (LPP) points to a close relationship to lichen planus. The Koebner phenomenon or isomorphic reaction has been described in lichen planus, LPP, and ultimately FFA, with face-lift procedures and hair restoration surgery having been implicated as the culprits in the latter. We report the first case of FFA in whom LPP developed at the sites of wig attachments, providing the evidence for Koebner phenomenon. Therefore, wigs are to be included to the list of procedures for hair restoration at risk of eliciting an isomorphic reaction in patients with FFA. Ultimately, the association of Koebner phenomenon with LPP-type lesions in FFA may provide further insight into the underlying pathology and nosology of the condition.
额部纤维性脱发(FFA)是一种独特的疾病,表现为沿额部和颞部发际线的边缘性瘢痕性脱发。自首次描述以来,人们认识到该病代表的是一种比局限性过程更广泛的疾病,其范围超出额颞部发际线,包括顶枕部发际线,并累及特殊的面部丘疹,这是面部毳毛受累和身体外周毛发脱落的证据。最后,FFA与口腔扁平苔藓、指甲受累以及伴发的扁平苔藓样毛发角化病(LPP)之间的关联表明其与扁平苔藓关系密切。Koebner现象或同形反应已在扁平苔藓、LPP以及最终的FFA中被描述,面部提升手术和毛发修复手术被认为是后者的诱因。我们报告了首例FFA患者在假发佩戴部位出现LPP的病例,为Koebner现象提供了证据。因此,假发应被列入有引发FFA患者同形反应风险的毛发修复手术清单。最终,FFA中Koebner现象与LPP型病变的关联可能会为该病的潜在病理学和疾病分类学提供进一步的见解。