Al Heialy Saba, Hachim Mahmood Yaseen, Hachim Ibrahim Yaseen, Bin Naeem Kashif, Hannawi Haifa, Lakshmanan Jeyaseelan, Al Salmi Issa, Hannawi Suad
College of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai, United Arab Emirates.
Meakins-Christie Laboratories, Research Institute of the McGill University Health Center, Montreal, Quebec, Canada.
Saudi J Biol Sci. 2021 Feb;28(2):1445-1450. doi: 10.1016/j.sjbs.2020.11.081. Epub 2020 Dec 3.
Obesity has been described as a significant independent risk factors of COVID-19. We aimed to study the association between obesity, co-morbidities and clinical outcomes of COVID-19.
Clinical data from 417 patients were collected retrospectively from the Al Kuwait Hospital, Ministry of Health and Prevention (MOHAP), Dubai, United Arab Emirates, who were admitted between March and June 2020. Patients were divided according to their body mass index (BMI). Various clinical outcomes were examined: presenting symptoms, severity, major co-morbidities, ICU admission, death, ventilation, ARDS, septic shock and laboratory parameters.
The average BMI was 29 ± 6.2 kg/m. BMI alone was not associated with the outcomes examined. However, class II obese patients had more co-morbidities compared to other groups. Hypertension was the most significant co-morbidity associated with obesity. Patients with BMI above the average BMI (29 kg/m) and presence of underlying co-morbidities showed significant increase in admission to ICU compared to patients below 29 kg/m and underlying co-morbidities (21.7% Vs. 9.2%), ARDS development (21.7% Vs. 10.53%), need for ventilation (8.3% Vs. 1.3%), and mortality (10% Vs. 1.3%).
Our data suggests that presence of underlying co-morbidities and high BMI work synergistically to affect the clinical outcomes of COVID-19.
肥胖已被描述为2019冠状病毒病（COVID-19）的一个重要独立危险因素。我们旨在研究肥胖、合并症与COVID-19临床结局之间的关联。
回顾性收集了2020年3月至6月期间入住阿拉伯联合酋长国迪拜卫生与预防部（MOHAP）科威特医院的417例患者的临床资料。患者根据体重指数（BMI）进行分组。检查了各种临床结局：出现的症状、严重程度、主要合并症、入住重症监护病房（ICU）情况、死亡情况、通气情况、急性呼吸窘迫综合征（ARDS）、感染性休克及实验室参数。
平均BMI为29±6.2kg/m²。仅BMI与所检查的结局无关。然而，与其他组相比，II类肥胖患者有更多的合并症。高血压是与肥胖相关的最显著合并症。BMI高于平均BMI（29kg/m²）且存在基础合并症的患者与BMI低于29kg/m²且有基础合并症的患者相比，入住ICU的比例显著增加（21.7%对9.2%）、ARDS发生率增加（21.7%对10.53%）、需要通气的比例增加（8.3%对1.3%）以及死亡率增加（10%对1.3%）。
我们的数据表明，基础合并症的存在和高BMI协同作用会影响COVID-19的临床结局。
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