Shilpi Kumari, Potekar R M
Department of Pathology, Shri. B.M. Patil Medical College, Hospital and Research Centre, Solapur road, Vijayapura, Karnataka 586103 India.
Indian J Hematol Blood Transfus. 2018 Jan;34(1):115-120. doi: 10.1007/s12288-017-0825-9. Epub 2017 May 8.
Altered platelets have been reported in patients with diabetes mellitus and has been considered as a 'prothrombotic state' with enhanced platelet reactivity. They have been associated with increased risk of vascular complications in these patients. Platelet indices correlate with functional status of platelets and is an emerging risk factor of vascular complications in diabetes. The study was undertaken to know the efficacy of platelet analysis in assessing the prognosis of diabetes mellitus. A prospective hospital based study of platelet parameters MPV, PDW and P-LCR was carried out on 280 cases diagnosed with Type 2 diabetes Mellitus and 280 controls with normal blood glucose levels. The blood glucose levels and HbA1c level were also measured. Statistical evaluation was performed by using Student's unpaired test and Pearson correlation test. The average age of presentation with type 2 diabetes mellitus was 53 ± 5.7 years. The mean duration of diabetes was 4.7 ± 2.5 years. MPV, PDW and P-LCR were significantly higher in diabetics compared to non diabetics (11.3 ± 1.0 vs. 9.0 ± 0.6, 14.2 ± 2.5 vs. 10.7 ± 0.7 fl, 35.0 ± 8.1 vs. 23.0 ± 2.4%). Among the diabetics, MPV, PDW and P-LCR were higher in those with complications as compared to those without complications, which was not statistically significant. The higher values of MPV, PDW and P-LCR indicates that they serve as better risk indicator of initial vascular complications in diabetes mellitus patients and can be used as a simple and cost effective tool to assess vascular events.
糖尿病患者中已报道存在血小板改变，并被认为是一种血小板反应性增强的“血栓前状态”。这些改变与这些患者血管并发症风险增加有关。血小板指标与血小板功能状态相关，是糖尿病血管并发症的一个新兴危险因素。本研究旨在了解血小板分析在评估糖尿病预后中的作用。对280例诊断为2型糖尿病的患者和280例血糖水平正常的对照者进行了一项基于医院的前瞻性血小板参数MPV、PDW和P-LCR研究。同时测量了血糖水平和糖化血红蛋白水平。采用学生氏非配对检验和Pearson相关检验进行统计学评估。2型糖尿病患者的平均就诊年龄为53±5.7岁。糖尿病的平均病程为4.7±2.5年。与非糖尿病患者相比，糖尿病患者的MPV、PDW和P-LCR显著更高（11.3±1.0对9.0±0.6，14.2±2.5对10.7±0.7fl，35.0±8.1对23.0±2.4%）。在糖尿病患者中，有并发症者的MPV、PDW和P-LCR高于无并发症者，但差异无统计学意义。MPV、PDW和P-LCR的较高值表明它们可作为糖尿病患者初始血管并发症更好的风险指标，并且可作为评估血管事件的一种简单且经济有效的工具。
