Yonata Ade, Ali Zulkhair, Indrajaya Taufik, Bahar Erial, Effendi Ian, Suhaimi Novadian, Suprapti Suprapti
Department of Internal Medicine, Faculty of Medicine, Lampung University, Bandar Lampung 35141, Indonesia.
Department of Internal Medicine, Faculty of Medicine, Sriwijaya University, Palembang 30126, Indonesia.
Int J Nephrol. 2020 Nov 9;2020:8893653. doi: 10.1155/2020/8893653. eCollection 2020.
Chronic kidney disease (CKD) is associated with high mortality rates, mainly as a result of cardiovascular complications. Meanwhile, recent studies have suggested a role of a homodimer protein called activin A in chronic kidney disease-mineral and bone disorder (CKD-MBD) conditions that may exist in the vascular calcification and osteolytic process. Ultrasound examination of the carotid intima-media thickness (cIMT) is a noninvasive method to assess vascular calcification. This study aimed to analyze the relationship between the activin A serum level and cIMT in patients with CKD at Mohammad Hoesin Hospital, Palembang, Indonesia.
We conducted a hospital-based, cross-sectional study of consecutive CKD patients at the Department of Internal Medicine, Mohammad Hoesin Hospital, from July to November 2019. The level of activin A was measured by enzyme-linked immunosorbent assay. Meanwhile, cIMT measurements were collected by -mode ultrasound imaging.
A total of 55 patients with CKD were included in this investigation. The median serum activin A level in these patients was 236.17 (116.33-283) pg/mL, while the median cIMT was 0.8 (0.6-1.45) mm. A relationship between the serum activin A level and cIMT ( = 0.449; = 0.001) was observed. During multivariate analysis with linear regression, triglyceride ( = 0.049), phosphate ( = 0.005), and activin A ( = 0.020) serum levels were factors associated with cIMT.
In this study, a relationship between the activin A serum level and cIMT in patients with CKD was identified. Vascular calcification should be screened for in all CKD patients by the measurement of cIMT.
慢性肾脏病（CKD）与高死亡率相关，主要是心血管并发症所致。同时，近期研究表明，一种名为激活素A的同二聚体蛋白在慢性肾脏病 - 矿物质和骨代谢紊乱（CKD - MBD）中发挥作用，该紊乱可能存在于血管钙化和骨溶解过程中。颈动脉内膜中层厚度（cIMT）的超声检查是评估血管钙化的一种非侵入性方法。本研究旨在分析印度尼西亚巨港穆罕默德·霍辛医院CKD患者血清激活素A水平与cIMT之间的关系。
我们于2019年7月至11月在穆罕默德·霍辛医院内科对连续性CKD患者进行了一项基于医院的横断面研究。激活素A水平通过酶联免疫吸附测定法测量。同时，通过B型超声成像收集cIMT测量值。
本研究共纳入55例CKD患者。这些患者血清激活素A水平的中位数为236.17（116.33 - 283）pg/mL，而cIMT的中位数为0.8（0.6 - 1.45）mm。观察到血清激活素A水平与cIMT之间存在相关性（r = 0.
