George Holly, Haslett E, Macheta Mac
Blackpool Victoria Hospital, Whinney Heys Road, FY3 8NR, UK.
Case Rep Womens Health. 2020 Nov 19;29:e00272. doi: 10.1016/j.crwh.2020.e00272. eCollection 2021 Jan.
We present a rare case of Coombs-negative autoimmune haemolytic anaemia in a multiparous woman in secondary care. There were no known underlying medical or obstetric risk factors for haemolytic anaemia. Following extensive investigation and a therapeutic trial of oral corticosteroids, a diagnosis was made. Autoimmune haemolytic anaemia is potentially fatal, and prompt diagnosis with haematology input is essential to ensure maternal and fetal safety in pregnancy and the puerperium. With only a small number of cases of Coombs-negative autoimmune haemolytic anaemia reported in the literature, we present this rare case for discussion. We highlight the importance of thorough investigation of refractory anaemia in pregnancy and consider the associated challenges.
我们报告了一例在二级医疗机构中，一位经产妇发生的库姆斯试验阴性自身免疫性溶血性贫血的罕见病例。该患者不存在已知的导致溶血性贫血的基础内科或产科危险因素。经过广泛检查及口服糖皮质激素的治疗性试验后，做出了诊断。自身免疫性溶血性贫血可能会致命，血液科参与的及时诊断对于确保孕期及产褥期母婴安全至关重要。鉴于文献中仅报道了少数库姆斯试验阴性自身免疫性溶血性贫血病例，我们呈现此罕见病例以供讨论。我们强调了对孕期难治性贫血进行全面检查的重要性，并考虑了相关挑战。
