Kulkarni Radhika, Basheer Amjad, Khan Aziz
UCONN Health, Farmington, CT, USA.
Eur J Case Rep Intern Med. 2021 Apr 8;8(4):002477. doi: 10.12890/2021_002477. eCollection 2021.
Epstein-Barr virus (EBV) is notorious for its varied presentation in adults. Reactivation of EBV can occur at any time and is often due to weakened cellular immunity.
Here we report the case of a young woman with no previous medical history who presented with cholestatic hepatitis, Coombs-negative haemolytic anaemia and splenomegaly. Due to the initial disjointed picture with no other localizing symptoms, she underwent extensive work-up for the same.
EBV has been associated with many malignancies, autoimmune diseases and chronic fatigue syndrome. EBV causes elevated liver enzymes; however, cholestatic hepatitis is exceedingly rare, with only a few cases reported. Haemolytic anaemia is a common complication of EBV infection and is often Coombs positive.
EBV testing should be considered before more invasive and expensive work-up in a patient presenting with multi-systemic abnormalities.
Epstein-Barr virus (EBV) can have myriad manifestations in all age groups.Coombs-negative haemolytic anaemia can occur as a complication of EBV.EBV testing should be considered prior to more expensive work-up in anyone presenting with abnormalities in the reticuloendothelial system.
爱泼斯坦-巴尔病毒（EBV）因其在成人中表现多样而声名狼藉。EBV的重新激活可在任何时候发生，且通常是由于细胞免疫功能减弱。
在此，我们报告一例既往无病史的年轻女性病例，该患者表现为胆汁淤积性肝炎、库姆斯试验阴性的溶血性贫血和脾肿大。由于最初症状不连贯且无其他定位症状，她为此接受了全面检查。
EBV与许多恶性肿瘤、自身免疫性疾病和慢性疲劳综合征有关。EBV可导致肝酶升高；然而，胆汁淤积性肝炎极为罕见，仅有少数病例报道。溶血性贫血是EBV感染的常见并发症，且通常库姆斯试验呈阳性。
对于出现多系统异常的患者，在进行更具侵入性和昂贵的检查之前，应考虑进行EBV检测。
爱泼斯坦-巴尔病毒（EBV）在所有年龄组中都可能有多种表现。库姆斯试验阴性的溶血性贫血可作为EBV的并发症出现。对于任何出现网状内皮系统异常的患者，在进行更昂贵的检查之前应考虑进行EBV检测。
