Nnodim J O
Department of Anatomy, College of Medical Sciences, University of Benin, Nigeria.
Anat Rec. 1987 Dec;219(4):331-7. doi: 10.1002/ar.1092190402.
Studies on the development of brown and white adipose tissues and their relationship to ordinary connective tissue are the subject of the present review, which is updated to the fall of 1985. Primordial entities described as "primitive organs" have been noted at sites of adipose tissue development by numerous investigators. These "primitive organs" are clearly delineated from surrounding connective tissue and possess a well-defined vascular network in the interstices of which cellular organization takes place. The precursor cells of brown and white adipocytes appear to acquire their distinctive cytogenetic properties at a very early stage in the embryo. These progenitor cells temporarily exhibit structural similarities to fibroblasts and endothelial cells. This resemblance has led to speculation that fibroblasts and/or endothelial cells may be ancestral to adipocytes. However, recent in vivo and in vitro observations suggest that the brown adipose precursor cell is morphogenetically distinct from the white adipose precursor cell on one hand, and from fibroblasts and endothelial cells on the other. In vitro studies have also shown that the pericytic elements present in both brown and white adipose tissue depots in the adult are quiescent precursor cells that may be recruited under certain circumstances. Areas for further inquiry by means of recently developed techniques are indicated.
棕色和白色脂肪组织的发育及其与普通结缔组织关系的研究是本综述的主题，本综述更新至1985年秋季。许多研究者在脂肪组织发育部位发现了被描述为“原始器官”的原始实体。这些“原始器官”与周围结缔组织界限分明，在其间隙中拥有明确的血管网络，细胞组织在其中发生。棕色和白色脂肪细胞的前体细胞似乎在胚胎发育的早期阶段就获得了其独特的细胞遗传学特性。这些祖细胞暂时表现出与成纤维细胞和内皮细胞的结构相似性。这种相似性引发了一种推测，即成纤维细胞和/或内皮细胞可能是脂肪细胞的祖先。然而，最近的体内和体外观察表明，棕色脂肪前体细胞一方面在形态发生上与白色脂肪前体细胞不同，另一方面也与成纤维细胞和内皮细胞不同。体外研究还表明，成年棕色和白色脂肪组织库中的周细胞成分是静止的前体细胞，在某些情况下可能被募集。文中指出了利用最近开发的技术进行进一步探究的领域。
