School of Optometry, The Hong Kong Polytechnic University, Hong Kong SAR, China.
Department of Ophthalmology, The University of Hong Kong, Hong Kong SAR, China.
Ophthalmic Physiol Opt. 2021 Mar;41(2):431-436. doi: 10.1111/opo.12774. Epub 2020 Dec 8.
To investigate the repeatability of pupil size measurements, determined from the NIDEK OPD-Scan III, of myopic eyes in children wearing single-vision spectacles (SVS), undergoing orthokeratology (OK) and receiving combined treatment of 0.01% atropine and orthokeratology (AOK).
A single examiner took two sets of mesopic pupil size measurements from the right eyes of 80 children (SVS:16, OK: 34, AOK: 30) (mesopic 1 and mesopic 2) and two sets of photopic (photopic 1 and photopic 2) pupil size measurements (internal light source) using the NIDEK OPD-Scan III. Each set was taken at a single visit, 15 min apart. Subjects in the OK and AOK groups had undergone treatment for at least 6 months, and the SVS subjects had no previous myopia treatment other than wearing spectacles. Repeatability of measurements was analysed using intraclass correlation coefficient (ICC), Bland-Altman (BA) plot, and coefficient of repeatability (CoR).
Mesopic 1 and 2 values were not significantly different among the three groups (p = 0.56, 0.77), hence the data were pooled for each set of measurements (mean [±S.D.] values were 7.09 ± 0.61 and 7.12 ± 0.61 mm, respectively) for further analyses. ICC for repeated mesopic pupil size measurements was 0.98 (95% CI, 0.98-0.99). No significant correlation was found between the means of the mesopic 1 and 2 measurements and their differences (Pearson's r = -0.02, p = 0.83). A BA plot also demonstrated narrow 95% limits of agreement, with a CoR of 0.28 mm. Mean photopic 1 and 2 measurements for the AOK group (3.74 ± 0.46; 3.73 ± 0.43 mm, respectively) were significantly larger (p = 0.01; 0.009) than those of the SVS and OK groups, but no significant difference was found between the latter two groups (p > 0.05). Hence, photopic 1 and 2 measurements for the SVS and OK groups were pooled (SVS-OK) for further analyses. ICC for repeatability of the photopic measurements was 0.98 (95% CI, 0.96 to 0.99) for the SVS-OK and AOK groups. The differences between photopic 1 and 2 measurements were not significantly correlated with their means, either in the AOK group (Pearson's r = -0.25, p = 0.19), or in the pooled SVS-OK group (Pearson's r = -0.04, p = 0.78). BA plots also showed narrow 95% limits of agreement, and CoR was 0.25 mm and 0.23 mm in the AOK and pooled SVS-OK groups, respectively.
Mesopic and photopic pupil size measurement using the NIDEK OPD-Scan III was highly repeatable and suitable for use on children.
研究使用尼德克 OPD-Scan III 对配戴单光眼镜（SVS）、接受角膜塑形术（OK）和接受 0.01%阿托品联合角膜塑形术（AOK）的近视儿童的瞳孔大小测量值的可重复性。
一名检查者对 80 名儿童（SVS：16 名，OK：34 名，AOK：30 名）（暗视 1 和暗视 2）右眼的两组中值瞳孔大小（暗视 1 和暗视 2）和两组明视瞳孔大小（明视 1 和明视 2）（内部光源）进行测量。每组在一次就诊时相隔 15 分钟进行两次测量。OK 和 AOK 组的受试者接受了至少 6 个月的治疗，SVS 组除了戴眼镜外，没有进行过其他近视治疗。使用组内相关系数（ICC）、Bland-Altman（BA）图和可重复性系数（CoR）分析测量的可重复性。
三组之间暗视 1 和 2 值无显著性差异（p=0.56，0.77），因此将每组测量数据合并（平均值[±标准差]分别为 7.09±0.61 和 7.12±0.61mm）进行进一步分析。暗视瞳孔大小的 ICC 为 0.98（95%可信区间，0.98-0.99）。暗视 1 和 2 测量值的平均值及其差异之间无显著相关性（Pearson r=-0.02，p=0.83）。BA 图也显示了狭窄的 95%一致性界限，CoR 为 0.28mm。AOK 组的明视 1 和 2 测量值（3.74±0.46；3.73±0.43mm）明显大于 SVS 和 OK 组（p=0.01；0.009），但后两组之间无显著差异（p>0.05）。因此，SVS 和 OK 组的明视 1 和 2 测量值被合并（SVS-OK）进行进一步分析。SVS-OK 和 AOK 组的明视测量值的 ICC 为 0.98（95%可信区间，0.96 至 0.99）。AOK 组（Pearson r=-0.25，p=0.19）或合并的 SVS-OK 组（Pearson r=-0.04，p=0.78）中，明视 1 和 2 测量值的差异与其平均值均无显著相关性。BA 图也显示了狭窄的 95%一致性界限，AOK 组和合并的 SVS-OK 组的 CoR 分别为 0.25mm 和 0.23mm。
使用尼德克 OPD-Scan III 进行中值和明视瞳孔大小测量具有高度可重复性，适用于儿童。
