Pavia D, Agnew J E, Sutton P P, Lopez-Vidriero M T, Clay M M, Killip M, Clarke S W
Department of Thoracic Medicine, Royal Free Hospital, London.
Br J Dis Chest. 1987 Oct;81(4):361-70. doi: 10.1016/0007-0971(87)90185-9.
Tracheobronchial mucus clearance was measured in nine mild asthmatics, using an objective radioaerosol technique, on 3 separate days at intervals of 1 week. Immediately after radioaerosol inhalation, drug or placebo was administered via subcutaneous injection (SC) plus metered dose inhaler (MDI)--2 puffs. Three randomized treatments were used: saline placebo SC plus 2 mg terbutaline by MDI (1 mg per puff); 0.25 mg terbutaline SC plus placebo (propellants and surfactant only) by MDI; and double placebo. Changes in lung mucociliary clearance showed an inverse relationship to baseline clearance of both proximal and distal ciliated airways following inhaled terbutaline, whereas terbutaline SC related inversely only to baseline clearance of the distal ciliated airways. This may reflect the surface concentrations of drug, established by each route.
采用客观的放射性气溶胶技术，在3个不同日期、间隔1周对9名轻度哮喘患者的气管支气管黏液清除情况进行了测量。在吸入放射性气溶胶后，立即通过皮下注射（SC）加定量吸入器（MDI）——2喷，给予药物或安慰剂。使用了三种随机治疗方法：生理盐水安慰剂皮下注射加2毫克特布他林定量吸入（每喷1毫克）；0.25毫克特布他林皮下注射加安慰剂（仅含推进剂和表面活性剂）定量吸入；以及双重安慰剂。吸入特布他林后，肺黏液纤毛清除的变化与近端和远端纤毛气道的基线清除呈负相关，而皮下注射特布他林仅与远端纤毛气道的基线清除呈负相关。这可能反映了每种给药途径所形成的药物表面浓度。
