甲状腺癌转移至咽旁和咽后间隙：系统回顾并报道七例新病例，描述一种常见疾病的不常见表现。
Metastatic thyroid carcinoma to the parapharyngeal and retropharyngeal spaces: Systematic review with seven newly reported cases describing an uncommon presentation of a common disease.
机构信息
Thyroid, Head and Neck Cancer (THANC) Foundation, New York, New York, USA.
Department of Otolaryngology-Head and Neck Surgery, Icahn School of Medicine at Mount Sinai Hospital, New York, New York, USA.
出版信息
Head Neck. 2021 Apr;43(4):1331-1344. doi: 10.1002/hed.26572. Epub 2020 Dec 9.
BACKGROUND
Metastatic thyroid carcinoma to retropharyngeal and parapharyngeal (RP/PP) lymph nodes is rare. Literature suggests previous lateral neck dissection (LND) may alter patterns of lymphatic drainage in the neck, predisposing to these less common sites of spread.
METHODS
PRISMA-guided systematic search for all published cases detailing RP/PP metastases of well-differentiated thyroid carcinoma from 1970 to 2019.
RESULTS
Seventy articles were identified and 44 were included, along with seven cases treated at our institution, totaling 239 cases. Cases represented both retropharyngeal (60.7%) and parapharyngeal (39.3%) metastases identified in the initial (27.6%) and recurrent (72.4%) setting.
CONCLUSION
RP/PP metastases generally present in the recurrent setting. RP/PP metastases often represent high-risk disease, and surgical treatment is recommended.
背景
甲状腺癌转移至咽后和咽旁（RP/PP）淋巴结的情况较为罕见。文献表明，先前的颈侧方清扫术（LND）可能改变颈部的淋巴引流模式，从而使这些不太常见的转移部位更容易发生转移。
方法
根据 PRISMA 指南对 1970 年至 2019 年所有详细描述分化型甲状腺癌 RP/PP 转移的已发表病例进行系统搜索。
结果
共确定了 70 篇文章，其中 44 篇被纳入，加上我们机构治疗的 7 例，共 239 例。这些病例既有初次（27.6%）发现的咽后（60.7%）转移，也有复发（72.4%）时发现的咽旁（39.3%）转移。
结论
RP/PP 转移通常出现在复发的情况下。RP/PP 转移通常代表高危疾病，建议进行手术治疗。
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