节段性早老综合征的遗传学研究如何记录了基因组不稳定性是衰老的标志，但现在让我们追求抗早老综合征！
Review of How Genetic Research on Segmental Progeroid Syndromes Has Documented Genomic Instability as a Hallmark of Aging But Let Us Now Pursue Antigeroid Syndromes!
机构信息
Department of Laboratory Medicine and Pathology, University of Washington, Seattle.
Division of Medical Genetics, Department of Medicine, University of Washington, Seattle.
出版信息
J Gerontol A Biol Sci Med Sci. 2021 Jan 18;76(2):253-259. doi: 10.1093/gerona/glaa273.
The purpose of this early contribution to the new Fellows Forum of this pioneering journal for what is now called Geroscience is to provide an example of how the author's interest in using the emerging tools of human genetics has led to strong support for one of the hallmarks of aging-Genomic Instability. We shall also briefly review our emerging interests in the genetic analysis of what we have called Antigeroid Syndromes. While there has been significant progress in that direction via genetic studies of centenarians, the search for genetic pathways that make individuals unusually resistant or resilient to the ravages of specific geriatric disorders has been comparatively neglected. We refer to these disorders as Unimodal Antigeroid Syndromes. It is our hope that our young colleagues will consider research efforts in that direction.
这篇早期文章是为这本开拓性期刊的新院士论坛做出的贡献，旨在为大家展示作者如何运用新兴的人类遗传学工具，来支持衰老的一个标志性特征——基因组不稳定性。我们还将简要回顾我们在所谓的抗老化综合征的遗传学分析方面的新兴兴趣。虽然通过对百岁老人的遗传研究已经取得了重大进展，但对于寻找使个体对特定老年疾病的破坏具有异常抗性或弹性的遗传途径的研究相对较少。我们将这些疾病称为单峰抗老化综合征。我们希望年轻的同事们能够考虑朝这个方向开展研究工作。
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