Crump Institute for Molecular Imaging and Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA, Los Angeles, CA, USA.
Mol Imaging. 2020 Jan-Dec;19:1536012120973099. doi: 10.1177/1536012120973099.
New platforms are enabling radiochemistry to be carried out in tiny, microliter-scale volumes, and this capability has enormous benefits for the production of radiopharmaceuticals. These droplet-based technologies can achieve comparable or better yields compared to conventional methods, but with vastly reduced reagent consumption, shorter synthesis time, higher molar activity (even for low activity batches), faster purification, and ultra-compact system size. We review here the state of the art of this emerging direction, summarize the radiotracers and prosthetic groups that have been synthesized in droplet format, describe recent achievements in scaling up activity levels, and discuss advantages and limitations and the future outlook of these innovative devices.
新平台使放射性化学能够在微小的微升规模下进行，这一能力为放射性药物的生产带来了巨大的好处。与传统方法相比，这些基于液滴的技术可以实现可比或更好的产率，但试剂消耗大大减少，合成时间更短，摩尔活性更高（即使是低活性批次），纯化更快，系统体积超紧凑。在这里，我们回顾了这一新兴方向的最新技术，总结了以液滴形式合成的放射性示踪剂和修饰基团，描述了最近在提高放射性活度水平方面的成就，并讨论了这些创新设备的优势、局限性和未来前景。
