Department of Obstetrics, The First Affiliated Hospital of China Medical University, Shenyang, China.
Department of Ultrasound, Shengjing Hospital of China Medical University, Shenyang, China.
Pregnancy Hypertens. 2021 Mar;23:87-90. doi: 10.1016/j.preghy.2020.11.009. Epub 2020 Dec 3.
Pre-eclampsia (PE) is a leading cause of maternal and fetal morbidity and mortality. Our aim was to assess epicardial adipose tissue (EAT) thickness as a potential effective screening parameter to predict PE in the first trimester.
133 women with PE were enrolled in this study, and divided into the early-onset and late-onset subgroups. 150 healthy women were enrolled as control group. Anthropometric and echocardiographic parameters were obtained, including EAT thickness. Generalized linear models was used to assess the predict efficiency of EAT with fdds ratio (OR) and 95% confidence intervals (CIs).
Compared to the controls, EAT thickness was higher in PE patients (P < 0.05). Multivariate regression analysis indicated that EAT thickness was associated with PE risk (OR = 1.50, 95%CI: 1.19-1.88, P < 0.05). The area under curves of EAT thickness was 0.616. When the cutoff value for EAT thickness was set to 5.26 mm, the sensitivity was 78.2% and the specificity was 44.7%. EAT thickness significantly both higher in the early-onset and late-onset groups compared to the controls; Meanwhile, EAT thickness was higher in the early-onset group than late-onset group (P < 0.05). Logistic regressionrevealed the close relationship between onset time of PE and EAT thickness (OR = 1.59, 95%CI: 1.28-1.98, P < 0.001).
Measured EAT thickness using echocardiography could identify high-risk people for PE as early as the first trimester. Echocardiographic EAT has the potential to be a predictor for PE prior to actual clinical diagnosis.
子痫前期（PE）是孕产妇和围产儿发病率和死亡率的主要原因。我们的目的是评估心外膜脂肪组织（EAT）厚度作为预测早期妊娠 PE 的潜在有效筛查参数。
本研究纳入了 133 例 PE 患者，并分为早发型和晚发型亚组。150 例健康女性纳入对照组。获得了包括 EAT 厚度在内的人体测量学和超声心动图参数。使用广义线性模型评估 EAT 与 fdds 比值（OR）和 95%置信区间（CI）的预测效率。
与对照组相比，PE 患者的 EAT 厚度更高（P<0.05）。多变量回归分析表明，EAT 厚度与 PE 风险相关（OR=1.50，95%CI：1.19-1.88，P<0.05）。EAT 厚度的曲线下面积为 0.616。当 EAT 厚度的截断值设定为 5.26mm 时，灵敏度为 78.2%，特异性为 44.7%。EAT 厚度在早发型和晚发型组均显著高于对照组（均 P<0.05）；同时，早发型组 EAT 厚度高于晚发型组（P<0.05）。Logistic 回归显示，PE 的发病时间与 EAT 厚度密切相关（OR=1.59，95%CI：1.28-1.98，P<0.001）。
使用超声心动图测量 EAT 厚度可以在妊娠早期识别出高危人群患 PE。超声心动图 EAT 有可能在实际临床诊断之前预测 PE。
