Department of obstetrics and gynecology, The First People's Hospital of Yuhang District, Hangzhou, Zhejiang, China.
Department of Cardiology, The First People's Hospital of Yuhang District, Hangzhou, Zhejiang, China.
Hypertens Pregnancy. 2024 Dec;43(1):2390531. doi: 10.1080/10641955.2024.2390531. Epub 2024 Aug 11.
Preeclampsia (PE) increases the risk of many adverse maternal and fetal outcomes. This study was to investigate the correlation between epicardial adipose tissue (EAT) thickness and PE and birth weight.
This was a single-center retrospective study, 221 patients with PE were selected, and 81 women without hypertension and proteinuria were selected as a comparison. Echocardiogram was performed in their first prenatal examinations at 11-13 gestational weeks, and the thickness of EAT was measured. At the subsequent follow-up, the birth weight was recorded.
EAT thickness was significantly elevated (6.60 ± 1.34 vs. 5.71 ± 1.79 mm, < 0.001) in severe PE compared to mild PE. In the multivariate analysis, EAT thickness (OR 5.671, 95% CI, 1.991-16.150, = 0.001), and C reactive protein (OR 4.097, 95% CI, 2.323-7.224, < 0.001) were found as significant independent predictors of severe PE after adjusting for other risk factors. Linear regression analysis showed that hs-CRP, EAT thickness, and severe PE significantly negatively affected birth weight.
EAT thickness can be used to identify pregnant women with severe PE risks and low birth weight. It is an independent risk factor for severe PE but is not a valuable sign of mild PE.
子痫前期（PE）会增加许多不良母婴结局的风险。本研究旨在探讨心外膜脂肪组织（EAT）厚度与 PE 和出生体重的相关性。
这是一项单中心回顾性研究，共纳入 221 例 PE 患者，并选择 81 例无高血压和蛋白尿的女性作为对照。在 11-13 孕周的首次产前检查中进行超声心动图检查，测量 EAT 厚度。在随后的随访中，记录出生体重。
与轻度 PE 相比，重度 PE 患者的 EAT 厚度明显升高（6.60±1.34 vs. 5.71±1.79mm， < 0.001）。在多因素分析中，EAT 厚度（OR 5.671，95%CI，1.991-16.150， = 0.001）和 C 反应蛋白（OR 4.097，95%CI，2.323-7.224， < 0.001）被发现是重度 PE 的独立预测因素，调整了其他危险因素。线性回归分析表明，hs-CRP、EAT 厚度和重度 PE 显著负影响出生体重。
EAT 厚度可用于识别有发生重度 PE 和低出生体重风险的孕妇。它是重度 PE 的独立危险因素，但对轻度 PE 无明显价值。
