Negrotto Laura, Marrodan Mariano, Fiol Marcela P, Gaitán María I, Ysrraelit María C, Vrech Carlos, Pappolla Agustín, Miguez Jimena, Patrucco Liliana, Cristiano Edgardo, Rojas Juan I, Carrá Adriana, Chertcoff Aníbal, Steinberg Judith, Martinez Alejandra D, Curbelo María C, Cohen Leila, Alonso Ricardo, Garcea Orlando, Pita Cecilia, Silva Berenice, Luetic Geraldine, Deri Norma, Balbuena María E, Tkachuk Verónica, Carnero Contentti Edgar, Lopez Pablo A, Pettinicchi Juan Pablo, Caride Alejandro, Burgos Marcos, Leguizamon Felisa, Knorre Eduardo, Piedrabuena Raúl, Barboza Andrés, Liwacki Susana, Nofal Pedro, Volman Gabriel, Alves Pinheiro Amelia, Hryb Javier, Tavolini Darío, Blaya Patricio, Recchia Luciano, Mainella Carolina, Kohler Matías, Kohler Eduardo, Blanche Jorge, Tizio Santiago, Saladino María L, Caceres Fernando, Fernández Liguori Nora, Lazaro Luciana, Zanga Gisela, Parada Marcilla Marcela, Fracaro María E, Pagani Cassara Fátima, Vazquez Guido, Sinay Vladimiro, Sgrilli Gustavo, Divi Pablo, Jacobo Miguel, Silva Emanuel, Reich Edgardo, Cabrera Lorena M, Menichini María L, Coppola Mariano, Martos Iván, Viglione Juan Pablo, Jose Gustavo, Bestoso Santiago, Manzi Rubén, Giunta Diego, Doldan María L, Alonso Serena Marina, Correale Jorge
Neuroimmunology Unit - FLENI, Montañeses 2325, CABA, Argentina.
Neuroimmunology Unit - FLENI, Montañeses 2325, CABA, Argentina.
Mult Scler Relat Disord. 2020 Nov;46:102582. doi: 10.1016/j.msard.2020.102582. Epub 2020 Oct 13.
Like MS prevalence, oligoclonal bands (OCB) frequency seems to follow a latitudinal gradient. Argentina is extensive, latitude-wise, and previous studies have not found an MS prevalence latitudinal gradient. Our aim is to describe OCB prevalence in MS, clinically isolated syndrome (CIS) and radiologically isolated syndrome (RIS) patients included in the Argentinean MS and NMOSD registry (RelevarEM) and to investigate if it follows a latitudinal gradient.
For each province, an average latitude was calculated, and OCB frequency was investigated. Multivariate logistical regression analysis and linear correlation were performed. Statistical analysis was repeated after excluding patients from centers using isoelectric focusing (IEF) in less than 95% of patients (CwIEF<95).
We included 2866 patients. OCB where positive in 73.9% of patients. No association or correlation were found between OCB and latitude of residence, even after excluding patients from (CwIEF<95).
OCB positivity does not follow a latitudinal gradient in Argentina. Also, OCB positivity is lower than described in other world regions.
与多发性硬化症（MS）患病率一样，寡克隆带（OCB）频率似乎也呈现出纬度梯度。阿根廷地域广阔，从纬度角度来看，先前的研究并未发现MS患病率存在纬度梯度。我们的目的是描述阿根廷MS和视神经脊髓炎谱系障碍（NMOSD）登记处（RelevarEM）纳入的MS、临床孤立综合征（CIS）和放射学孤立综合征（RIS）患者中OCB的患病率，并调查其是否遵循纬度梯度。
计算每个省份的平均纬度，并调查OCB频率。进行多变量逻辑回归分析和线性相关分析。在排除使用等电聚焦（IEF）的中心中患者比例低于95%（CwIEF<95）的患者后，重复进行统计分析。
我们纳入了2866例患者。73.9%的患者OCB呈阳性。即使排除（CwIEF<95）的患者后，也未发现OCB与居住纬度之间存在关联或相关性。
在阿根廷，OCB阳性率不遵循纬度梯度。此外，OCB阳性率低于世界其他地区的描述。
