Colnaghi Luca, Rondelli Diego, Muzi-Falconi Marco, Sertic Sarah
Department of Molecular Biochemistry and Pharmacology, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Via Negri 2, 20156 Milan, Italy.
Dipartimento di Bioscienze, Università degli Studi di Milano, Via Celoria 26, 20133 Milan, Italy.
Brain Sci. 2020 Dec 7;10(12):946. doi: 10.3390/brainsci10120946.
Neurodegenerative disorders are a family of incurable conditions. Among them, Alzheimer's disease and tauopathies are the most common. Pathological features of these two disorders are synaptic loss, neuronal cell death and increased DNA damage. A key pathological protein for the onset and progression of the conditions is the protein tau, a microtubule-binding protein highly expressed in neurons and encoded by the (microtubule-associated protein tau) gene. Tau is predominantly a cytosolic protein that interacts with numerous other proteins and molecules. Recent findings, however, have highlighted new and unexpected roles for tau in the nucleus of neuronal cells. This review summarizes the functions of tau in the metabolism of DNA, describing them in the context of the disorders.
神经退行性疾病是一类无法治愈的病症。其中，阿尔茨海默病和tau蛋白病最为常见。这两种疾病的病理特征是突触丧失、神经元细胞死亡和DNA损伤增加。引发和推动这些病症的一个关键病理蛋白是tau蛋白，它是一种在神经元中高度表达且由（微管相关蛋白tau）基因编码的微管结合蛋白。Tau主要是一种胞质蛋白，可与许多其他蛋白质和分子相互作用。然而，最近的研究结果突出了tau在神经元细胞核中的新的意外作用。本综述总结了tau在DNA代谢中的功能，并结合这些病症对其进行描述。
