Department of Pharmaceutics, SRM College of Pharmacy, SRM Institute of Science and Technology, Kattankulathur, Chennai, Tamilnadu-603203, India.
Centre for Molecular Biology, Institute of Research and Development, Duy Tan University, 03 Quang Trung, Da Nang, Vietnam.
Curr Diabetes Rev. 2021;17(4):486-495. doi: 10.2174/1573399817666201209095205.
Conventional delivery of antidiabetic drugs faces many problems like poor absorption, low bioavailability, and drug degradation. Nanoemulsion is a unique drug technology, which is very suitable for the delivery of antidiabetic drugs. In recent years, the flaws of delivering anti-hypoglycaemic drugs have been overcome by choosing nanoemulsion drug technology. They are thermodynamically stable and also provide the therapeutic agent for a longer duration. Generally, nanoemulsions are made up of either oil-in-water or water-in-oil and the size of the droplets is from fifty to thousand nanometer. Surfactants are critical substances that are added in the manufacturing of nanoemulsions. Only the surfactants which are approved for human use can be utilized in the manufacturing of nanoemulsions. Generally, the preparation of emulsions includes mixing of the aqueous phase and organic phase and using surfactant with proper agitation. Nanoemulsions are used for antimicrobial drugs, and they are also used in the prophylaxis of cancer. Reduction in the droplet size may cause variation in the elastic and optical behaviour of nanoemulsions.
传统的抗糖尿病药物输送面临许多问题，如吸收不良、生物利用度低和药物降解。纳米乳剂是一种独特的药物技术，非常适合输送抗糖尿病药物。近年来，通过选择纳米乳剂药物技术，克服了输送抗低血糖药物的缺陷。它们热力学稳定，还能提供更长时间的治疗药物。通常，纳米乳剂由油包水或水包油组成，液滴的大小从五十到一千纳米不等。表面活性剂是制造纳米乳剂时添加的关键物质。只有经批准可用于人体的表面活性剂才能用于制造纳米乳剂。一般来说，乳液的制备包括水相和有机相的混合，以及使用适当搅拌的表面活性剂。纳米乳剂用于抗菌药物，也用于癌症的预防。液滴尺寸的减小可能会导致纳米乳剂弹性和光学行为的变化。
