药师咨询对孕妇生活质量的影响，特别关注恶心和呕吐：一项干预研究。
The effect of a pharmacist consultation on pregnant women's quality of life with a special focus on nausea and vomiting: an intervention study.
机构信息
Pharmacoepidemiology and Drug Safety Research Group, Department of Pharmacy, University of Oslo, Oslo, Norway.
The Norwegian Pharmacy Association, Oslo, Norway.
出版信息
BMC Pregnancy Childbirth. 2020 Dec 9;20(1):766. doi: 10.1186/s12884-020-03472-z.
BACKGROUND
Maternal wellbeing and quality of life (QOL) are increasingly being recognized as important for healthy pregnancies. The aim of this study was to investigate the impact of a pharmacist consultation on pregnant women's QOL focusing on nausea and vomiting in pregnancy (NVP), and patient satisfaction.
METHODS
For this intervention study in 14 community pharmacies, women in early pregnancy were recruited and assigned to a pharmacist consultation (intervention) or standard care (control). The consultation aimed to address each woman's concerns regarding medications and pregnancy-related ailments. Data were collected through online questionnaires at baseline (Q1) and during the second trimester (Q2). The intervention group completed an additional satisfaction questionnaire after the consultation was completed. The primary outcome was the impact of the intervention on the Quality of Life Scale (QOLS) scores between the first and second trimesters. The impact of the intervention was assessed by linear regression, and secondary analyses were performed to assess effect modification by NVP.
RESULTS
Of the 340 women enrolled in the study, we analyzed data for 245. Half (170/340) of the original participants were allocated to the intervention group, of whom 131 received the pharmacist consultation. Most women (75%, 78/96) reported that the consultation was useful to a large/very large extent. The consultation had no overall impact on QOLS scores between the first and the second trimesters compared with standard care (adjusted β: 0.7, 95% CI: -2.1, 3.4). The impact of the intervention on QOLS was greater amongst women with moderate/severe NVP (adjusted β: 3.6, 95% CI: -0.6, 7.7) compared to those with no/mild NVP (adjusted β: -1.4, 95% CI: -5.1, 2.2) (interaction term study group*NVP severity, p = 0.048).
CONCLUSIONS
The pregnant women highly appreciated the pharmacist consultation, but the intervention did not affect their QOL scores compared with standard care. Future studies should further explore the effect of a pharmacist consultation specifically for NVP and on other outcomes such as use of health care services and medication use in pregnancy.
TRIAL REGISTRATION
Retrospectively registered in ClinicalTrials.gov (identifier: NCT04182750 , registration date: December 2, 2019).
背景
孕产妇健康和生活质量（QOL）越来越被认为是健康妊娠的重要因素。本研究旨在探讨药剂师咨询对孕妇生活质量（重点关注妊娠恶心和呕吐[NVP]）的影响，以及患者满意度。
方法
在 14 家社区药店进行这项干预研究，招募了处于早孕阶段的女性，并将其分配至药剂师咨询（干预组）或标准护理（对照组）。咨询旨在解决每位女性对药物和妊娠相关疾病的担忧。在基线（Q1）和妊娠中期（Q2）通过在线问卷收集数据。干预组在咨询结束后完成了额外的满意度问卷。主要结局是干预对第一和第二孕期之间生活质量量表（QOLS）评分的影响。通过线性回归评估干预的影响，并进行二次分析以评估 NVP 对干预效果的修饰作用。
结果
在纳入的 340 名女性中，我们对 245 名女性进行了数据分析。最初的 340 名参与者中有一半（170/340）被分配到干预组，其中 131 名接受了药剂师咨询。大多数女性（75%，78/96）表示咨询在很大/非常大程度上有用。与标准护理相比，咨询对第一和第二孕期之间的 QOLS 评分没有总体影响（调整后的β：0.7，95%CI：-2.1，3.4）。在 NVP 中度/重度的女性中，干预对 QOLS 的影响大于无/轻度 NVP 的女性（调整后的β：3.6，95%CI：-0.6，7.7），而无/轻度 NVP 的女性（调整后的β：-1.4，95%CI：-5.1，2.2）（交互项研究组*NVP 严重程度，p=0.048）。
结论
孕妇非常赞赏药剂师的咨询，但与标准护理相比，咨询并未影响她们的 QOL 评分。未来的研究应进一步探讨专门针对 NVP 以及其他结局（如医疗保健服务的使用和怀孕期间的用药）的药剂师咨询的效果。
试验注册
在 ClinicalTrials.gov 上进行了回顾性注册（标识符：NCT04182750，注册日期：2019 年 12 月 2 日）。
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