Havnen Gro C, Truong Maria Bich-Thuy, Do Mai-Linh H, Heitmann Kristine, Holst Lone, Nordeng Hedvig
a Regional Medicines Information and Pharmacovigilance Centre (RELIS) , Oslo University Hospital , Oslo , Norway.
b PharmacoEpidemiology and Drug Safety Research Group, Department of Pharmacy , University of Oslo , Oslo , Norway.
Scand J Prim Health Care. 2019 Mar;37(1):30-40. doi: 10.1080/02813432.2019.1569424. Epub 2019 Mar 1.
Hyperemesis gravidarum (HG) affects 0.3-3% of pregnant women and is a leading cause of hospitalization in early pregnancy. The aim of the study was to investigate women's treatment and management of HG, as well as the consequences of HG on women's daily life.
A cross-sectional study based on a structured telephone interview and an online questionnaire. Participants were recruited by social media and by the Norwegian patient's organization for HG.
Norwegian women that experienced HG.
Women's perspectives on management and consequences of HG.
The study included 107 women. Maternal morbidity was profound; about 3/4 of participants were hospitalized due to HG, and the majority showed clinical signs of dehydration (79%), ketonuria (75%), and >5% weight loss (84%). Antiemetics were used by >90% and frequently prescribed "as needed". Metoclopramide (71%) and meclozine (51%) were most commonly used. Participants described HG as having severe psychosocial consequences and profound impact on daily activities. Almost two out of five reported thoughts of elective abortion, and 8 women had at least one elective pregnancy termination due to HG. Overall, 20 women (19%) changed GPs due to dissatisfaction with HG management.
Despite the high psychosocial burden and major impact on daily activities, many women with HG reported a lack of support from healthcare professionals and suboptimal management. Greater awareness and knowledge among healthcare professionals is needed to improve care for women with HG. Key Points There is a paucity of studies on management and the consequences of HG on women's daily lives and psychosocial burden. We found that: • Many women described HG as one of their worst life experiences with profound morbidity. • Many women reported suboptimal management of HG and lack of support from healthcare professionals. • Greater understanding of patient perspectives among healthcare professionals is important to improve care and management for HG patients.
妊娠剧吐（HG）影响0.3% - 3%的孕妇，是孕早期住院的主要原因。本研究旨在调查女性对妊娠剧吐的治疗与管理情况，以及妊娠剧吐对女性日常生活的影响。
一项基于结构化电话访谈和在线问卷的横断面研究。通过社交媒体和挪威妊娠剧吐患者组织招募参与者。
经历过妊娠剧吐的挪威女性。
女性对妊娠剧吐管理及影响的看法。
该研究纳入了107名女性。孕产妇发病率很高；约3/4的参与者因妊娠剧吐住院，大多数有脱水（79%）、酮尿（75%）和体重减轻>5%（84%）的临床症状。超过90%的人使用了止吐药，且经常按“需要”开具。最常用的是胃复安（71%）和氯苯甲嗪（51%）。参与者称妊娠剧吐会产生严重的心理社会后果，并对日常活动有深远影响。近五分之二的人表示有过选择性流产的想法，8名女性因妊娠剧吐至少进行过一次选择性终止妊娠。总体而言，20名女性（19%）因对妊娠剧吐管理不满意而更换了全科医生。
尽管妊娠剧吐会带来很高的心理社会负担并对日常活动有重大影响，但许多妊娠剧吐女性表示缺乏医护人员的支持且管理欠佳。医护人员需要提高认识和知识水平，以改善对妊娠剧吐女性的护理。要点 关于妊娠剧吐的管理以及对女性日常生活和心理社会负担影响的研究较少。我们发现：• 许多女性将妊娠剧吐描述为她们最糟糕的生活经历之一，发病率很高。• 许多女性报告妊娠剧吐管理欠佳且缺乏医护人员的支持。• 医护人员更好地理解患者观点对于改善妊娠剧吐患者的护理和管理很重要。
