Department of Life Science, College of Natural Sciences, Hanyang University, Seoul 04763; Research Institute for Natural Sciences, Hanyang University, Seoul 04763; Research Institute for Convergence of Basic Sciences, Hanyang University, Seoul 04763, Korea.
BMB Rep. 2021 Feb;54(2):89-97. doi: 10.5483/BMBRep.2021.54.2.212.
Post-transcriptional regulation is an indispensable cellular mechanism of gene expression control that dictates various cellular functions and cell fate decisions. Recently, various chemical RNA modifications, termed the "epitranscriptome," have been proposed to play crucial roles in the regulation of post-transcriptional gene expression. To date, more than 170 RNA modifications have been identified in almost all types of RNA. As with DNA modification-mediated control of gene expression, regulation of gene expression via RNA modification is also accomplished by three groups of proteins: writers, readers, and erasers. Several emerging studies have revealed that dysregulation in RNA modification is closely associated with tumorigenesis. Notably, the molecular outcomes of specific RNA modifications often have opposite cellular consequences. In this review, we highlight the current progress in the elucidation of the mechanisms of cancer development due to chemical modifications of various RNA species. [BMB Reports 2021; 54(2): 89-97].
转录后调控是基因表达调控中不可或缺的细胞机制，决定着各种细胞功能和细胞命运决定。最近，各种化学 RNA 修饰被称为“转录后组”，被认为在调节转录后基因表达中起着关键作用。迄今为止，几乎所有类型的 RNA 中已经鉴定出超过 170 种 RNA 修饰。与 DNA 修饰介导的基因表达调控一样，通过 RNA 修饰调节基因表达也是由三组蛋白完成的：写入器、读取器和橡皮擦。一些新出现的研究表明，RNA 修饰的失调与肿瘤发生密切相关。值得注意的是，特定 RNA 修饰的分子结果通常具有相反的细胞后果。在这篇综述中，我们强调了由于各种 RNA 种类的化学修饰而导致癌症发展的机制的最新进展。[BMB 报告 2021;54(2):89-97]。
