Jani S K, Hitchon P W, VanGilder J C, Pennington E C, Hussey D H
Division of Radiation Oncology, University of Iowa Hospitals and Clincs, Iowa City.
Appl Neurophysiol. 1987;50(1-6):295-301. doi: 10.1159/000100730.
In stereotactic interstitial radiotherapy, small radioactive sources are placed within the brain tumor to deliver locally high radiation doses. The choice of the radioisotope depends upon the dose distribution around the isotope, energy of the emitted radiation, relative biological effectiveness, and finally, the cost and availability of the isotope. We have analyzed 198gold, 125iodine and 192iridium in terms of these four factors. Our results have shown that 125I is superior to the other two isotopes due to its soft X-rays and dosimetric as well as radiobiological properties. Unfortunately, it is the most expensive of these radioisotopes, and can be difficult to obtain in specific activities.
在立体定向间质放射治疗中，将小型放射源置于脑肿瘤内以局部给予高剂量辐射。放射性同位素的选择取决于同位素周围的剂量分布、发射辐射的能量、相对生物效应，最后还取决于同位素的成本和可获得性。我们已根据这四个因素对198金、125碘和192铱进行了分析。我们的结果表明，125碘由于其软X射线以及剂量学和放射生物学特性而优于其他两种同位素。不幸的是，它是这些放射性同位素中最昂贵的，并且在特定活度下可能难以获得。
