Zhang Ting, Jia Yanni, Li Suxia, Shi Weiyun
Eye Hospital of Shandong First Medical University, Jinan, China.
State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Shandong Eye Institute, Shandong First Medical University & Shandong Academy of Medical Sciences, Qingdao, China.
J Ophthalmol. 2020 Nov 23;2020:8437479. doi: 10.1155/2020/8437479. eCollection 2020.
To evaluate the efficacy of individualized corneal patching using a minimal graft for corneal trauma combined with tissue defects.
Fifteen eyes (15 patients) were enrolled in this study, including 8 eyes with corneal perforation induced by removal of metal foreign bodies, 5 eyes with corneal laceration resulting from metal trauma, and 2 eyes with pencil injuries to the cornea. The size, shape, and depth of the tissue defects were assessed. For corneal perforation or irregular tissue defects, if the diameter or length was ≥3.0 mm, traditional penetrating keratoplasty (PK) or lamellar keratoplasty (LK) was adopted; if the diameter or length was <3.0 mm, a conical or irregular patch consistent with the defects was used. The visual acuity, corneal status, and postoperative complications were observed during the follow-up.
The diameter of corneal perforations was 1.0 mm in 2 eyes, 1.5 mm in 1 eye, 2.0 mm in 4 eyes, and 3.5 mm in 1 eye. During their PK procedures, a conical corneal graft was used in 7 eyes, while a traditional cylindrical graft was used in 1 eye. The other 7 eyes had corneal trauma combined with irregular tissue defects, which were full-thickness corneal defects in 5 eyes and lamellar defects in 2 eyes, all less than 3.0 mm in length. Thus, five eyes received PK, and 2 eyes received LK using an irregular wedge-shaped patch. The visual acuity increased greatly postoperatively, with mild corneal astigmatism. None of the patients developed immune rejection.
Individualized corneal patching with a minimal graft can save corneal materials, relieve corneal scars, gain a good visual prognosis, and avoid immune rejection in the treatment of corneal trauma combined with tissue defects.
评估使用最小移植片进行个体化角膜修补术治疗角膜外伤合并组织缺损的疗效。
本研究纳入15只眼(15例患者),其中8只眼因取出金属异物导致角膜穿孔,5只眼因金属外伤导致角膜裂伤,2只眼因铅笔扎伤角膜。评估组织缺损的大小、形状和深度。对于角膜穿孔或不规则组织缺损,若直径或长度≥3.0 mm,则采用传统穿透性角膜移植术(PK)或板层角膜移植术(LK);若直径或长度<3.0 mm,则使用与缺损相符的圆锥形或不规则补片。随访期间观察视力、角膜状况及术后并发症。
2只眼角膜穿孔直径为1.0 mm,1只眼为1.5 mm,4只眼为2.0 mm,1只眼为3.5 mm。在PK手术中,7只眼使用圆锥形角膜移植片,1只眼使用传统圆柱形移植片。另外7只眼角膜外伤合并不规则组织缺损,其中5只眼为全层角膜缺损,2只眼为板层缺损,长度均小于3.0 mm。因此,5只眼接受了PK,2只眼使用不规则楔形补片接受了LK。术后视力显著提高,角膜散光轻微。所有患者均未发生免疫排斥反应。
使用最小移植片进行个体化角膜修补术在治疗角膜外伤合并组织缺损时可节省角膜材料,减轻角膜瘢痕,获得良好的视力预后,并避免免疫排斥反应。