Department of Anesthesiology, West China Second Hospital of Sichuan University, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, Chengdu, China.
Department of Gynecology and Obstetrics, West China Second Hospital of Sichuan University, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, Chengdu, China.
Biomed Res Int. 2020 Nov 25;2020:1392674. doi: 10.1155/2020/1392674. eCollection 2020.
Few studies have reported the function of LYNX1 in ovarian cancer. We retrieved LYNX1 gene expression data and clinical information of 376 patients with ovarian cancer from The Cancer Genome Atlas (TCGA) project website. Wilcoxon signed-rank test and logistic regression were used to analyze the relationship between clinical pathologic features and LYNX1 expression. The Kaplan-Meier method was used to draw survival curves of patients, and Cox regression was used to calculate the relationship between LYNX1 expression and survival rate or the clinicopathological characteristics of the patients. Gene set enrichment analysis (GSEA) was performed, and the correlation between LYNX1 expression and cancer immune infiltrates was investigated via single sample gene set enrichment analysis (ssGSEA). High LYNX1 expression in ovarian serous cystadenocarcinoma (OVs) was associated with tumor residual disease (RD). In Kaplan-Meier survival analysis, patients with OVs who also displayed high LYNX1 expression had decreased overall survival (OS) and disease-specific survival (DSS) than those with low LYNX1 expression. Univariate analysis also supported that patients with high LYNX1 expression had lower OS than those with low LYNX1 expression. LYNX1 expression has the potential to be a prognostic molecular marker of poor survival in OVs.
鲜有研究报道 LYNX1 在卵巢癌中的作用。我们从癌症基因组图谱（TCGA）项目网站中检索了 376 名卵巢癌患者的 LYNX1 基因表达数据和临床信息。采用 Wilcoxon 符号秩检验和逻辑回归分析 LYNX1 表达与临床病理特征之间的关系。Kaplan-Meier 法绘制患者生存曲线，Cox 回归计算 LYNX1 表达与生存率或患者临床病理特征之间的关系。进行基因集富集分析（GSEA），通过单样本基因集富集分析（ssGSEA）研究 LYNX1 表达与癌症免疫浸润之间的相关性。在卵巢浆液性囊腺癌（OVs）中，LYNX1 的高表达与肿瘤残留疾病（RD）相关。在 Kaplan-Meier 生存分析中，LYNX1 高表达的 OVs 患者的总生存（OS）和疾病特异性生存（DSS）均低于 LYNX1 低表达的患者。单因素分析也支持 LYNX1 高表达的患者 OS 低于 LYNX1 低表达的患者。LYNX1 表达可能是 OVs 患者预后不良的分子标志物。
