Alveirinho Manuel, Freitas Paula, Faleiro Maria Leonor
Programa Doutoral em Metabolismo - Clínica e Experimentação, Faculdade de Medicina, Universidade do Porto.
Serviço de Endocrinologia do Centro Hospitalar e Universitário São João; Faculdade de Medicina da Universidade do Porto, I3S - Instituto de Investigação e Inovação em Saúde, Porto.
Porto Biomed J. 2020 Dec 3;5(6):e105. doi: 10.1097/j.pbj.0000000000000105. eCollection 2020 Nov-Dec.
The metabolic syndrome is a complex entity comprised of multiple cardiovascular risk factors grouped in a single individual, contributing to an increased rate of cardiovascular events which goes beyond what would be expected given the impact of each individual risk factor. It is a multifactorial condition whose complete pathogenesis is not yet fully understood. Several studies have shown that not only the intestinal microbiota and dysbiosis may play a role in its pathogenesis, but also that modulating said microbiota may play a role in treating or at least ameliorating the metabolic syndrome. The purpose of this article is to review some of the most recent evidence linking the gut microbiome and the metabolic syndrome to help further understand this relationship and try to identify further research directions.
代谢综合征是一种复杂的病症，由聚集在同一个体中的多种心血管危险因素组成，会导致心血管事件发生率升高，这种升高程度超出了仅考虑每个单独危险因素影响时的预期。它是一种多因素疾病，其完整的发病机制尚未完全明确。多项研究表明，不仅肠道微生物群和菌群失调可能在其发病机制中起作用，而且调节上述微生物群可能在治疗或至少改善代谢综合征方面发挥作用。本文的目的是综述一些将肠道微生物组与代谢综合征联系起来的最新证据，以帮助进一步理解这种关系，并尝试确定进一步的研究方向。
