发育中大鼠的肾上腺多巴胺含量。甲状腺状态及胰岛素低血糖的影响。

Adrenal dopamine content of the developing rat. Influence of the thyroid status and insulin-hypoglycaemia.

作者信息

Gripois D, Valens M, Richter P, Genermont J

机构信息

Laboratoire d'Endocrinologie, Université Paris-Sud, Orsay, France.

出版信息

J Auton Nerv Syst. 1987 Dec;21(2-3):181-4. doi: 10.1016/0165-1838(87)90020-8.

DOI:10.1016/0165-1838(87)90020-8

PMID:3330087

Abstract

Neonatal hypothyroidism accelerates the postnatal evolution of the adrenal dopamine (DA) content and concentration in the young rat. In 14-day-old control animals, insulin-hypoglycaemia leads to a transient increase in adrenal dopamine content up to 159% above the value in saline-injected animals. This increase is already at its maximum 1 h after insulin administration and lasts 7 h. In the hypothyroid animals, the DA increase evoked by hypoglycaemia is impaired in magnitude (74%) and duration (4 h).

摘要

新生儿甲状腺功能减退会加速幼鼠出生后肾上腺多巴胺（DA）含量和浓度的变化。在14日龄的对照动物中，胰岛素低血糖会导致肾上腺多巴胺含量短暂增加，最高可比注射生理盐水的动物高出159%。这种增加在注射胰岛素后1小时即达到最大值，并持续7小时。在甲状腺功能减退的动物中，低血糖诱发的多巴胺增加在幅度（74%）和持续时间（4小时）上均受到损害。