可见光促进的涉及硫叶立德作为卡宾捕获试剂的多取代烯烃合成
Visible-Light-Promoted Polysubstituted Olefins Synthesis Involving Sulfur Ylides as Carbene Trapping Reagents.
作者信息
Ye Cong, Cai Bao-Gui, Lu Juan, Cheng Xiao, Li Lei, Pan Zhong-Wen, Xuan Jun
机构信息
Anhui Province Key Laboratory of Chemistry for Inorganic/Organic Hybrid Functionalized Materials and Key Laboratory of Functional Inorganic Materials of Anhui Province, College of Chemistry & Chemical Engineering, Anhui University, Hefei, Anhui 230601, People's Republic of China.
Key Laboratory of Structure and Functional Regulation of Hybrid Materials (Anhui University), Ministry of Education, Hefei 230601, People's Republic of China.
出版信息
J Org Chem. 2021 Jan 1;86(1):1012-1022. doi: 10.1021/acs.joc.0c02500. Epub 2020 Dec 10.
A blue-light-emitting diode (LED) promoted coupling of aryl diazoacetates with sulfur ylides is described. This protocol features mild conditions, good functional group tolerance, and broad substrate scope for both aryl diazoacetates with sulfur ylides. Under optimal reaction conditions, a wide range of trisubstituted olefins is obtained in moderate to good yield, which can be further transferred to other biologically important heterocycles after a two-step simple operation.
本文描述了一种蓝光发光二极管（LED）促进芳基重氮乙酸酯与硫叶立德的偶联反应。该方法具有反应条件温和、官能团耐受性好以及芳基重氮乙酸酯与硫叶立德的底物范围广等特点。在最佳反应条件下，能以中等至良好的产率得到多种三取代烯烃，经过两步简单操作后可进一步转化为其他具有生物学重要性的杂环化合物。
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