可见光促进的1,3-二羰基硫鎓叶立德的合成
Visible-Light-Promoted Synthesis of 1,3-Dicarbonyl Sulfoxonium Ylides.
作者信息
Echemendía Radell, de Oliveira Kleber T, Burtoloso Antonio C B
机构信息
Institute of Chemistry of São Carlos, University of São Paulo, CEP, 13560-970 São Carlos, SP, Brazil.
Department of Chemistry, Federal University of São Carlos, Campus São Carlos, 13565-905 São Carlos, SP, Brazil.
出版信息
Org Lett. 2022 Sep 9;24(35):6386-6390. doi: 10.1021/acs.orglett.2c02346. Epub 2022 Aug 26.
A novel visible-light-promoted coupling of diazoketones with sulfoxonium ylides, employing a violet light-emitting diode, is described under both batch and continuous flow conditions. This transformation permits the direct synthesis of synthetically useful 1,3-dicarbonyl sulfoxonium ylides (33 examples, 21-85% yields), by means of an acylation from the and selective generation of ketenes. The reaction performed under flow conditions proved to be very efficient, providing the 1,3-dicarbonyl sulfoxonium ylides with higher yields and shorter reaction times.
本文描述了一种在间歇和连续流动条件下，使用紫色发光二极管可见光促进重氮酮与亚砜叶立德偶联的新方法。这种转化允许通过酰化反应和烯酮的选择性生成，直接合成具有合成用途的1,3 - 二羰基亚砜叶立德（33个例子，产率21 - 85%）。在流动条件下进行的反应被证明非常有效，能够以更高的产率和更短的反应时间得到1,3 - 二羰基亚砜叶立德。
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