School of Chemical Engineering, Sichuan University, Chengdu, Sichuan 610065, P. R. China.
State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu, Sichuan 610065, P. R. China.
ACS Appl Mater Interfaces. 2020 Dec 23;12(51):57514-57525. doi: 10.1021/acsami.0c14656. Epub 2020 Dec 10.
In this work, a simple and flexible method for the fabrication of chitosan microcapsules with controllable structures and functions via the interfacial cross-linking reaction of the water-in-oil (W/O) emulsion templates is developed. The interfacial cross-linking reactions of chitosan and terephthalaldehyde (TPA) in W/O emulsion templates are comprehensively studied. The interfacial cross-linking reactions of the droplet templates in both batchwise and continuous conditions are studied. A poly(dimethylsiloxane) (PDMS) droplet-capture microfluidic chip is fabricated to investigate the interfacial reaction in continuous conditions online. In this study, the size and shell thickness of the microcapsules are affected by the preparation condition, such as the template size, emulsifier concentration, TPA concentration, and cross-linking time. Moreover, the size and shell thickness changes of chitosan microcapsules prepared in continuous conditions are much faster than those prepared in batchwise conditions. By regulating the preparation parameters, the microcapsules with controllable structures are fabricated in both batchwise and continuous conditions. The drug release behaviors of the microcapsules with controllable structures are studied. Furthermore, by adding magnetic nanoparticles to the aqueous solution, magnetic-responsive microcapsules are fabricated easily. This work provides valuable guidance for the controllable fabrication of chitosan microcapsules with designed structures and functions via single emulsion templates.
在这项工作中，开发了一种通过油水（W/O）乳液模板的界面交联反应来制造具有可控结构和功能的壳聚糖微胶囊的简单灵活的方法。全面研究了壳聚糖和对苯二甲醛（TPA）在 W/O 乳液模板中的界面交联反应。研究了批处理和连续条件下液滴模板的界面交联反应。制备了聚二甲基硅氧烷（PDMS）液滴捕获微流控芯片，在线研究连续条件下的界面反应。在这项研究中，微胶囊的尺寸和壳厚度受制备条件的影响，例如模板尺寸、乳化剂浓度、TPA 浓度和交联时间。此外，连续条件下制备的壳聚糖微胶囊的尺寸和壳厚度变化比批处理条件下快得多。通过调节制备参数，可以在批处理和连续条件下制备具有可控结构的微胶囊。研究了具有可控结构的微胶囊的药物释放行为。此外，通过向水溶液中添加磁性纳米粒子，很容易制备出磁响应微胶囊。这项工作为通过单乳液模板可控制备具有设计结构和功能的壳聚糖微胶囊提供了有价值的指导。
