Malmgren R, Collins A, Nilsson C G
Department of Experimental Surgery, Karolinska Institutet, Stockholm, Sweden.
Neuropsychobiology. 1987;18(2):83-6. doi: 10.1159/000118398.
The platelet serotonin uptake kinetics was studied in 19 women with premenstrual tension syndrome (PMS) and 19 age-matched symptom-free controls during the pre- and postmenstrual phases. Both groups exhibited stable Vmax and Km values at the two phases of the menstrual cycle. There were no differences between the two groups regarding the level of Vmax and Km, respectively. The effect of season (p less than 0.001), with lowered values of Vmax during spring compared to corresponding values during the later half of the year, was identical in both groups. A tendency to lowered Vmax values in the follicular phase in women with PMS during spring may indicate that women with PMS are more vulnerable to developing depressive episodes during this period than symptom-free women. The blood platelet count in whole blood was decreased in the luteal phase in the control group but remained stable in the PMS group. The effect of vitamin B6 on clinical symptoms and the platelet serotonin uptake during the luteal phase was investigated in a double-blind crossover design. Vitamin B6 treatment did not significantly improve the PMS symptoms. There was no effect of treatment on Km. Vmax increased significantly in response to treatment (F = 9.6; p less than 0.001) in both groups, but there was no significant difference between placebo and vitamin B6.
在月经前和月经后阶段，对19名患有经前紧张综合征（PMS）的女性和19名年龄匹配的无症状对照女性的血小板血清素摄取动力学进行了研究。两组在月经周期的两个阶段均表现出稳定的Vmax和Km值。两组在Vmax和Km水平上分别无差异。季节的影响（p<0.001），即春季的Vmax值低于下半年相应值，在两组中是相同的。春季患有PMS的女性在卵泡期Vmax值有降低的趋势，这可能表明患有PMS的女性在此期间比无症状女性更容易发生抑郁发作。对照组黄体期全血中的血小板计数降低，但PMS组保持稳定。采用双盲交叉设计研究了维生素B6对黄体期临床症状和血小板血清素摄取的影响。维生素B6治疗并未显著改善PMS症状。治疗对Km无影响。两组治疗后Vmax均显著增加（F = 9.6；p<0.001），但安慰剂组和维生素B6组之间无显著差异。
