Hagen I, Nesheim B I, Tuntland T
Acta Obstet Gynecol Scand. 1985;64(8):667-70. doi: 10.3109/00016348509158211.
Vitamin B-6 100 mg given daily throughout the menstrual cycle was compared with placebo in a randomized, double-blind crossover trial in 34 women who suffered from premenstrual tension. Vitamin B-6 was no better than placebo. There was a substantial period effect, as the women evidenced a considerable preference for the second drug they received, irrespective of whether this was vitamin B-6 or placebo. Blood magnesium was measured; no significant difference was found between the 34 women with premenstrual tension and 10 healthy women without such complaints. Vitamin B-6 caused a small but statistically significant rise in blood magnesium level. In the individual patients, no correlation was found between changes in blood magnesium and premenstrual symptoms.
在一项针对34名患有经前紧张症的女性的随机双盲交叉试验中，将整个月经周期每天服用100毫克维生素B-6与安慰剂进行了比较。维生素B-6并不比安慰剂效果更好。存在显著的阶段效应，因为这些女性明显更倾向于她们接受的第二种药物，无论这种药物是维生素B-6还是安慰剂。测量了血镁水平；在34名患有经前紧张症的女性和10名无此类症状的健康女性之间未发现显著差异。维生素B-6使血镁水平有小幅但具有统计学意义的升高。在个体患者中，未发现血镁变化与经前症状之间存在相关性。
