Department of Biochemistry, Central University of Rajasthan, Ajmer, 305817, India.
Department of Biochemistry, Central University of Rajasthan, Ajmer, 305817, India.
Drug Discov Today. 2021 Mar;26(3):704-712. doi: 10.1016/j.drudis.2020.12.002. Epub 2020 Dec 7.
Growing multidrug-resistant (MDR) strains of various infectious bacterial species are hindering research aiming to eliminate such infections. During a bacterial infection, the host response eliminates the pathogen via fusion of the endocytic vesicles with lysosomes, called xenophagy. However, MDR bacteria have evolved strategies to escape xenophagy. In this review, we propose novel therapeutics for overcoming such escape, including chimeric antibiotics, nanoformulations for the induction of autophagy in infected cells, and small interfering (si)RNA-mediated silencing of genes to inhibit the host-pathogen interaction. We also discuss the role of combinations of antibiotics showing synergy, the administrative routes of differentially capped nanoparticles (NPs), and the use of different types of nanoformulations for eliminating pathogenic bacteria from the host.
各种传染性细菌耐药性（MDR）菌株的不断增长，阻碍了旨在消除此类感染的研究。在细菌感染过程中，宿主通过内吞体与溶酶体融合来消除病原体，称为异噬作用。然而，MDR 细菌已经进化出逃避异噬作用的策略。在这篇综述中，我们提出了克服这种逃避的新疗法，包括嵌合抗生素、用于诱导感染细胞自噬的纳米制剂，以及通过小干扰（si）RNA 介导的基因沉默来抑制宿主-病原体相互作用。我们还讨论了显示协同作用的抗生素组合、不同封端纳米颗粒（NPs）的给药途径以及使用不同类型的纳米制剂从宿主中消除致病菌的作用。
