Department of Biomedical Science, Graduate School, Kyung Hee University, Seoul, Republic of Korea.
Department of Biochemistry and Molecular Biology, School of Medicine, Kyung Hee University, Seoul, Republic of Korea.
Lifestyle Genom. 2021;14(1):20-29. doi: 10.1159/000511333. Epub 2020 Dec 10.
Obesity results from an imbalance in the intake and expenditure of calories that leads to lifestyle-related diseases. Although genome-wide association studies (GWAS) have revealed many obesity-related genetic factors, the interactions of these factors and calorie intake remain unknown. This study aimed to investigate interactions between calorie intake and the polygenic risk score (PRS) of BMI.
Three cohorts, i.e., from the Korea Association REsource (KARE; n = 8,736), CArdioVAscular Disease Association Study (CAVAS; n = 9,334), and Health EXAminee (HEXA; n = 28,445), were used for this study. BMI-related genetic loci were selected from previous GWAS. Two scores, PRS, and association (a)PRS, were used; the former was determined from 193 single-nucleotide polymorphisms (SNPs) from 5 GWAS datasets, and the latter from 62 SNPs (potentially associated) from 3 Korean cohorts (meta-analysis, p < 0.01).
PRS and aPRS were significantly associated with BMI in all 3 cohorts but did not exhibit a significant interaction with total calorie intake. Similar results were obtained for obesity. PRS and aPRS were significantly associated with obesity but did not show a significant interaction with total calorie intake. We further analyzed the interaction with protein, fat, and carbohydrate intake. The results were similar to those for total calorie intake, with PRS and aPRS found to not be associated with the interaction of any of the 3 nutrition components for either BMI or obesity.
The interaction of BMI PRS with calorie intake was investigated in 3 independent Korean cohorts (total n = 35,094) and no interactions were found between PRS and calorie intake for obesity.
肥胖是由于热量摄入和消耗之间的不平衡导致的与生活方式相关的疾病。尽管全基因组关联研究（GWAS）已经揭示了许多与肥胖相关的遗传因素，但这些因素与热量摄入的相互作用仍不清楚。本研究旨在探讨热量摄入与 BMI 的多基因风险评分（PRS）之间的相互作用。
本研究使用了三个队列，即韩国关联资源（KARE；n=8736）、心血管疾病关联研究（CAVAS；n=9334）和健康检查（HEXA；n=28445）。BMI 相关的遗传位点从之前的 GWAS 中选择。使用了两个评分，PRS 和关联（a）PRS，前者由 5 个 GWAS 数据集的 193 个单核苷酸多态性（SNP）确定，后者由 3 个韩国队列的 62 个 SNP（可能相关）（荟萃分析，p<0.01）确定。
PRS 和 aPRS 与所有 3 个队列的 BMI 显著相关，但与总热量摄入没有显著的相互作用。肥胖的结果也相似。PRS 和 aPRS 与肥胖显著相关，但与总热量摄入没有显著的相互作用。我们进一步分析了与蛋白质、脂肪和碳水化合物摄入的相互作用。结果与总热量摄入相似，PRS 和 aPRS 与这 3 种营养成分的任何一种与 BMI 或肥胖的相互作用都没有关联。
在 3 个独立的韩国队列（总 n=35094）中研究了 BMI PRS 与热量摄入的相互作用，没有发现 PRS 与肥胖的热量摄入之间存在相互作用。
