"Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.
Fundeni Clinical Institute, Department of Anaesthesia and Intensive Care, Bucharest, Romania.
Int J Artif Organs. 2021 Aug;44(8):560-564. doi: 10.1177/0391398820981383. Epub 2020 Dec 10.
Acute liver failure (ALF) is a life-threatening disease associated with multi-organ failure and increased mortality. Severe inflammation is now considered the main pathophysiological mechanism for organ dysfunction, thus rebalancing pro- and anti- inflammatory cytokines may improve liver function and outcome. The aim of this study was to assess the clinical effects of a haemoadsorption column on biochemical parameters in patients with ALF. We prospectively included 28 patients with ALF who were treated with three consecutive sessions of continuous venovenous haemofiltration in combination with CytoSorb. Our results show an improvement in liver functional tests and a decrease in Creactive protein. Thrombocytopenia remains one of the most important side effects of this treatment and careful consideration should be made before initiation of treatment.
急性肝衰竭（ALF）是一种危及生命的疾病，可导致多器官衰竭和死亡率增加。严重的炎症现在被认为是器官功能障碍的主要病理生理机制，因此，重新平衡促炎和抗炎细胞因子可能会改善肝功能和预后。本研究旨在评估血液吸附柱对 ALF 患者生化参数的临床疗效。我们前瞻性地纳入了 28 例 ALF 患者，这些患者接受了连续三次的连续静脉-静脉血液滤过联合 CytoSorb 治疗。我们的结果显示，肝功能试验有所改善，C 反应蛋白降低。血小板减少仍然是这种治疗的最重要副作用之一，在开始治疗前应慎重考虑。
