Department of Dentistry, King's College London, London, United Kingdom.
Department of Dentistry, Universidade Estadual de Montes Claros, Minas Gerais, Brazil.
Protein Pept Lett. 2021;28(7):735-749. doi: 10.2174/0929866527999201209221012.
Oral cancer is a significant health problem worldwide. Oral squamous cell carcinoma (OSCC) is a malignant neoplasm of epithelial cells that mostly affects different anatomical sites in the head and neck and derives from the squamous epithelium or displays similar morphological characteristics. Generally, OSCC is often the end stage of several changes in the stratified squamous epithelium, which begin as epithelial dysplasia and progress by breaking the basement membrane and invading adjacent tissues. Several plant-based drugs with potent anti-cancer effects are considered inexpensive treatments with limited side effects for cancer and other diseases.
The aim of this review is to explore whether some Brazilian plant extracts or constituents exhibit anti-tumorigenic activity or have a cytotoxic effect on human oral carcinoma cells.
Briefly, OSCC and several metabolites derived from Brazilian plants (i.e., flavonoids, vinblastine, irinotecan, etoposide and paclitaxel) were used as keywords to search the literature on PubMed, GenBank and GeneCards.
The results showed that these five chemical compounds found in Cerrado Biome plants exhibit anti-neoplastic effects. Evaluating the compounds revealed that they play a main role in the regulation of cell proliferation.
Preserving and utilising the biodiversity of our planet, especially in unique ecosystems, such as the Cerrado Biome, may prove essential to preserving and promoting human health in modern contexts.
口腔癌是全球范围内一个重大的健康问题。口腔鳞状细胞癌（OSCC）是一种上皮细胞的恶性肿瘤，主要影响头颈部的不同解剖部位，来源于鳞状上皮或表现出相似的形态学特征。通常，OSCC 通常是复层鳞状上皮几种变化的终末阶段，这些变化始于上皮异型增生，并通过突破基底膜和侵犯相邻组织而进展。一些具有强大抗癌作用的植物源性药物被认为是治疗癌症和其他疾病的廉价方法，副作用有限。
本综述旨在探讨一些巴西植物提取物或成分是否对人口腔癌细胞具有抗肿瘤活性或细胞毒性作用。
简要地说，OSCC 和几种源自巴西植物的代谢物（如类黄酮、长春碱、伊立替康、依托泊苷和紫杉醇）被用作在 PubMed、GenBank 和 GeneCards 上搜索文献的关键词。
结果表明，在塞拉多生物群落植物中发现的这五种化学化合物具有抗肿瘤作用。评估这些化合物表明，它们在调节细胞增殖方面起着主要作用。
保护和利用我们星球的生物多样性，特别是在独特的生态系统中，如塞拉多生物群落，对于在现代背景下保护和促进人类健康可能至关重要。
