Department of Infectious Diseases, MD Anderson Cancer Center, 1515 Holcombe Boulevard, Box 1460, Houston, TX 77030, USA.
Department of Infectious Diseases, MD Anderson Cancer Center, 1515 Holcombe Boulevard, Box 1460, Houston, TX 77030, USA.
Infect Dis Clin North Am. 2021 Mar;35(1):199-217. doi: 10.1016/j.idc.2020.10.009. Epub 2020 Dec 7.
Skin and soft tissue infections among the non-human immunodeficiency virus infected immunosuppressed population are a serious and growing concern. Many pathogens can cause cutaneous infections in these patients owing to the highly varied and profound immune deficits. Although patients can be infected by typical organisms, the diversity and antimicrobial-resistant nature of the organisms causing these infections result in significant morbidity and mortality. The diagnostic approach to these infections in immunocompromised hosts can differ dramatically depending on the potential causative organisms. An understanding of new immunosuppressive treatments and evolving antimicrobial resistance patterns are required to optimally manage these difficult cases.
非艾滋病毒感染免疫抑制人群中的皮肤和软组织感染是一个严重且日益严重的问题。由于免疫缺陷高度多样化和深刻，许多病原体可导致这些患者的皮肤感染。尽管患者可能被典型的病原体感染，但导致这些感染的病原体的多样性和抗微生物耐药性导致了显著的发病率和死亡率。在免疫功能低下的宿主中，这些感染的诊断方法可能因潜在的致病生物体而有很大差异。为了最佳管理这些困难病例，需要了解新的免疫抑制治疗方法和不断发展的抗微生物耐药模式。
